My husband was recently prescribed fluoxetine for depression> Soon after beginning the treatment I noticed he had developed muscle twitches at night> After 4 months of taking the medication he decided to stop taking it and instead of coming off gradually stopped when his tablets ran out> Subsequently his twitching has been much worse, more like spasms or dyskenesia in his sleep. He wakes up with an unbearable restless or crawling sensations and sometimes this has kept him awake all night. He has been off the medication for over six weeks. It's exhausting.