I would advise anyone about to take Bonive, DON'T!!!!! I took the once a month dosage for 3 months and will NEVER take it again. First month had major upper stomach problems and muscle twitches. Didn't put the symptoms with the Boniva. Started to feel better by end of month, second month stomach upsets and muscle twitches, but by end of month waned. Third month, WATCH OUT! Day after taking third dose, felt like I got hit by a train. Felt terrible all over, but couldn't relax. Calf muscles ached and twitched, constant acid and sour taste in mouth. Now getting sores in mouth, also suffering from mood swings. I was once a happy healthy 53 yr old female, now I don't know if I will ever be the same. From what I have read about this poison, they call Boniva, it may take up to five years to fully leave your body. Just cause it workss for Sally, doesn't mean it will work for you!!!