I think everyone reacts differently to progesterone. I recently started an oral bio identical progesterone and have lost weight, not gained. I was having a very difficult time losing weight, having a lot mood swings and basically felt terrible. My physician checked my progesterone and it was low. Since I have started the progesterone I've lost 5 pounds and feel less bloated. (Less fluid retention) I feel much better on it, and I also take a small amount of bio identical testosterone. Something else may be "off" with you, or perhaps your dosage needs to be lowered or try an oral bio identical formula. Some women are very sensitive to progesterone. Sometimes changing dosage or delivery helps.