I've been on the WIley Protocol -2 for estrogen and standard progesterone for about three months. I get sort of mini-periods - two days, max. I felt wonderful when I first started, but now even on my high estrogen days I feel like it just isn't having an effect. My waist is thickening unattractively and I don't have very good energy. My skin is also going downhill and my sleep is barely OK. My doctor increased the estradiol dosage by one line, but it doesn't seem to make any difference.
Has anyone else experienced this? The estradiol working at first, and then the effect radically diminishing? What did you do?