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I have a best friend who has suffered with severe migraines for years. She participated in a clinical trial for Botox injections and has gotten some relief. Her trial is over now but the results were promising enough that her insurance company has now agreed to pay for her Botox treatments once every three months for two years to see if the relief continues. That started about six months ago; so far, she is at the same level of relief but the migraines have not gone away entirely; in fact, this weekend she had one that took at least two doses of her migraine medicine. A good month for her is when she has had only two or three migraines all month. She is continuing the Botox treatments with the hope that they will continue to help, but also isn't super-excited about having to get 31 (31!) small injections each time (in the forehead and back of the neck). Migraine treatment continues to be a rough road, with different things working for different people. Thanks so much for this post; I hope we hear from some other women who have some experience with this.