Interesting connection to BMI. A recent study with mild/moderate depression patients also found a significant link between depression (onset/duration/TRD) and a patient BMI over 30. It seems that patients with elevated BMI are often deficient in folate status (several studies). This is perhaps the first significant biomarker the will help physicians more effectively treat depression. Experts unveiled and discussed these principles during 2011 U.S. Psych Congress (November, Las Vegas). Use of the active form of folate (L-methylfolate) has been shown to overcome such a folate deficiency and spur the increased production of all three mood neurotransmitters: serotonin, dopamine and norepinephrine. Your thoughts?