Several points missing in this article---1. the 2002 WHI study used synthetic/monster hormones, and they were given orally. The hormones used in that study were not bioidentical, and yet nearly every media article you read lumps all hormones together. 2. True hormonal balance is not just sticking an estrogen patch on, I see nothing in this article about progesterone (and all women need progesterone---I haven't had a uterus in 9 years, and I have been taking progesterone for 5, it cured my hot flashes in 3 days, and my seasonal allergies, restless leg syndrome and acid reflux in less than 2 weeks) nor do I see any mention of testosterone. 3. The lowest dose for the shortest duration of time----why, because we are going to suddenly start generating our hormones again? Optimization of hormones goes way beyond just menopausal issues, hormones affect EVERY system in the body. My osteopenia was cured with testosterone optimization and Vitamin D (Vitamin D is a prohormone). I do not understand why this is still so controversial, women at the peri/menopausal transition have a hormone deficiency, not an antidepressant deficiency. If anyone would like a list of resources to help you find a doctor/compounding pharmacy in your area who deals with bioidentical hormones, please feel free to drop me a line at [email protected] and I will get the information right out to you. Best wishes to all for hormonal health!