I too out on 80 pounds while taking Lyrica. Watch out for it. I was taking Cymbalta with it as well and continue to take Cymbalta. I was able to lose 65 pounds once I tapered off the Lyrica (which took me six months. Ugh! The withdrawal was horrible), and I believe this last 15 pounds is from the Cymbalta. It works very well for me, so I've decided to make friends with these 15 pounds because I think they will be around for a while.