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hi anonymous, since 2006 nothing has worked for my depression I have tried so many different combinations of antidepressants they just don't work for me in just they just don't work I don't know why but I'm medication resistant so desperate I saw your article and wanted to reply I'm so glad it worked on your friend and maybe I have some hope maybe this would work I hope would be better than the other alternative deep deep severe major depressionyou could write me on more input I greatly appreciate it thank you so much. Danny Jo