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Hi Anonymous, Thak you for your question and welcome to Empowher. It is common to have irregular periods with liver issues. I am not sure what your exact liver issue is but this information may be helpful. Please click here https://www.empowher.com/menstrual-cycle/content/liver-function-can-affe.... I hope this helps. MissieDecember 11, 2011 - 11:50am