A nice attempt at addressing the issue of side effects with Bipolar Disorder.
In not only Bipolar II, but Bipolar I and NOS (Not otherwise specified, for Bipolar that doesn't fit in category I or II) the use of SSRI's are considered extremely risky. SSRI's often catapult someone from depression to mania in a matter of days. Since many people often initially just think they're depressed and seek treatment for depression, their Bipolar is discovered as a result of an SSRI induced mania.
Many advances have been made in psychopharmacology, but it doesn't fix this problem for everyone. Some people's brains just don't end up responding well enough to psych meds, which is called being "treatment resistant", and is a difficult hand to be dealt.