I've heard two different opinions on this and I'm wondering what the EmpowHer answer is.... I recently started taking a magnesium supplement (400mg) after the recommendation of our wondrous Coach Virginia due to my RLS issue. And I'm curious to know what time of the day would be most advantageous for me to take it, as far as absorption is concerned, so that I get the most benefit from it. I currently take Omeprazole, a proton pump inhibitor, first thing in the morning due to my GERD. I don't know if this would have any affect on how a supplement is absorbed. In the evening at bedtime, I take Yaz birth control pill. Those are the only meds I take and I take no other supplements. Thanks for any input you might have!