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My OB/GYN has me on SottoPelle bio hormones..for 6 mos now...I've had Trigonitis for 10 yrs..at least that's when they cystogram/camera i n bladder found Trigonitis..no telling how long I had it before then...I've read each comment from the members here..and it seems each one will have treatment with success...but then come back and report the Trigonitis has returned...so seems there isn't a cure yet..only treatment for relief...also seems making the urine more alkaline with tums and baking soda helps ! I'm 62 and it seems as we age things happen to the lining of the bladder...so maybe the new buzz now with Dr.s is hormones may help restore the bladder lining/trigone...just getting through the agony till it works and whatever helps for each one...I had one 8 oz glass of merlot wine...and it caused pain for days now...I will keep looking for new discoveries from the medical community...at one time my OB/GYN suggested a device implanted in my back to block the pain in bladder..but that scared me.