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Hi I am on Letrozole 5mg this month for fertility and having bad cramps and bloating and feeling on and off nauseated for 2 days now. I am on day 22 of my 28 day cycle. What could this be from?

By August 11, 2011 - 9:14pm
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My stomach and face are so bloated since i started taking letrozole. The nausea and fatigue have finally simmered down, started on my 3rd month. I do have a few minor body aches and major insomnia and hot flashes. I'm glad I'm not the only one bloating.

May 20, 2017 - 5:13pm

Hi Mellor,

Thank you for your question and welcome to EmpowHer!

The symptoms you are experiencing are a result of Letrozele. Nausea, stomach pains, and water retention (which will lead to bloating) are all common side effects of the medication.

Other common side effects include: Back, leg, or arm pain; breast pain; constipation; cough; diarrhea; dizziness; headache; hot flashes; flushing; increased sweating; indigestion; joint or muscle pain; loss of appetite; mild swelling or fluid retention; nausea; night sweats; sleeplessness; stomach pain; tiredness; vaginal dryness or irritation; vomiting; weakness; weight gain or loss.

More serious side effects that require medical attention include: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); calf pain or tenderness; chest pain; confusion; fever, chills, or sore throat; increased or painful urination; numbness of an arm or leg; one-sided weakness; severe or persistent bone pain; severe stomach pain; shortness of breath; sudden severe headache, vomiting, dizziness, or fainting; swelling of the ankles or feet; unexplained vaginal bleeding or discharge; vision or speech changes.

Hope this helps,


August 12, 2011 - 7:24am
EmpowHER Guest
Anonymous (reply to Rosa Cabrera RN)

Rosa. I am having numbness in 1 leg from letrozole.
I stopped taking it a week ago. My leg muscles twitch too. Do I still need to go to the DR since I stopped taking it.

October 27, 2017 - 5:59am
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