I'm 21 years old and have been on depo provera for around 3 years now. It has never affected my sex drive and I can't imagine it is now suddenly. It's like I just am never in the mood to have sex anymore. I used to have sex several times a week, at one point, I was having sex with my partner every day. I started taking Zoloft in September of 2011, but I stopped taking it in November 2011 and not long after, my sex drive seemed to return to mostly normal. It's just within the past month that my sex drive is gone again. I don't know what could be causing the problem. I must also admit, that I have been suffering with random spurts of depression recently too. It comes on suddenly and usually lingers several hours to a whole day before I feel like my normal self again. This has been happening pretty regularly lately and I'm not quite sure what is going on. I haven't had a period in over a year, so I can't imagine it's any form of PMS either. Can anyone shed any light on the situation? Also, I had my thyroid a few months ago and all my levels are normal, so that rules that out.