What causes serum blisters with severe itching with pain in surrounding tissue

Hello, Anon!

Thank you for posting today.

Blisters are most often caused by skin being damaged by friction or heat. Certain medical conditions also cause blisters to appear. The damaged upper layer of skin tears away from the layers beneath and fluid (serum) collects in the space to create a blister.

It's important to avoid bursting the blister because this could lead to infection or slow the healing process. If the blister does burst, don't peel off the dead skin. Instead, allow the fluid inside the blister to drain and cover the area with a dry, sterile dressing to protect it from infection until it heals. If the blister is very painful and you think it's infected (contains green or yellow pus) see your doctor.

Helena