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Yeast Infection: Which medicine (OTC) is the best?

By August 21, 2009 - 7:13am
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There are so many choices for over-the-counter medications for yeast infections, and I understand the difference between the suppositories, creams and wipes.

I'm curious, though, to know which of the suppositories are the best, or how do we find out? For instance, Monistat has the 7 day, 3 day, and two versions of a 1-day that contain different types of medication. Most of them have the active ingredient miconazole nitrate, but one of the 1-Day is tioconazole.

My questions are:
1. Are there any clinical studies that says one active ingredient works better?
2. Any research that says the 7 day, 3 day or 1 day treatments work better?


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EmpowHER Guest

I have tried both, and I recall them both giving such a horrible reaction. I felt like I was on fire. Once, I woke up and my vaginal lips were completely swollen, so I immediately went to my OBGYN, and even she couldn't figure it out. She made a few phone calls to other doctor friends of hers, and told me to take a Benadryl...... Yes that simple! Who would of thought something that simple is the solution right? I took it, and BOOM I went back to feeling GREAT! I tend to get a yeast infection maybe once a year, and I will only do the 1-day treatments. Both work fine, but now I just take a Benadryl as soon as I apply the 1-day treatment before bed, and I wake up feeling fine. Remember ladies BENADRYL!

February 2, 2018 - 3:01pm
EmpowHER Guest

i found that i am alergic to monistat and miconazole, i can only use clotrimazole, walgreens usually carries it, but it can be hard to find. monistat and miconazole burned it bad.

January 22, 2018 - 3:54pm
EmpowHER Guest

Actual facts that answer the question:

Most yeast infections are caused by a type of yeast called Candida albicans, but some are caused by the yeast Candida glabrata, which can be harder to treat.

Tioconazole (in use since 1983 RX /1997 OTC) is an antifungal treatment that is only available as a single dose, so all tioconazole yeast infection products are 1-Day treatments. Tioconazole is known to work against both Candida albicans and Candida glabrata, the two strains of yeast most common in vaginal yeast infections.

Miconazole (in use since 1974 RX /1991 OTC) is a broad spectrum antifungal that is used to treat a variety of skin conditions in addition to yeast infections. F. Miconazole is available as an active ingredient in 1-day, 3-day and 7-day treatment lengths and can be found in many forms, including creams and suppositories.

The SHORTER treatments contain HIGHER DOSES of medication per day. For some women, shorter treatment courses help avoid missed doses and make it easier to finish the treatment.

Combination packs offer a miconazole nitrate cream in addition to the vaginal product, that can be used externally for fast itch relief.

Vaginal products and oral tablets are equally effective: both non-prescription and prescription medications are about 80% - 90% effective for most women, no matter which medication or length of treatment you choose.

May 31, 2017 - 11:17am
EmpowHER Guest

Ticonazole 1 day burned me. I had to contact an online nurse because I was unsure if I should go to urgent care. I couldn't sit down; I thought it was going to fall off. I would never recommend it to anyone. Then it did not take care of the problem either. Next, I went to the 7 day Miconazole and this worked. Ladies I suggest the 7 day Miconazole or 3 day Miconazole to fix the YI.

May 22, 2017 - 8:27am
EmpowHER Guest

Whatever you do, I don't suggest the monistst brand!! My poor vag was in hell! Burn and painful itching.

November 6, 2016 - 10:25am
EmpowHER Guest

Tioconazole is an antifungul targeted specifically to vaginal yeast infections whereas miconazole is a broad spectrum antifungal can treat several types of fungi infections not specifically vaginal

April 29, 2016 - 10:18am
EmpowHER Guest

Tioconazole caused an allergic reaction for me, probably because it's stronger.

April 13, 2016 - 5:49am
EmpowHER Guest

Once you start to feel like you may be getting a yeast infection, you need to take a supplement right away - as it will kill the Candida yeast that causes yeast infections. It wont cause harm. Right when I get the small feeling that I may be getting a yeast infection, I take 2 Lady Soma Candida Cleanse pills and then two more at night. Usually, I wont get an infection at all. If I do not take them soon enough, and I end up with a yeast infection, I just take 4 right away, and it clears up in 24 hours. Its natural and does not have side effects.

February 7, 2016 - 2:09pm
EmpowHER Guest

Folks here are missing the fact that all 1 day treatments are less effective than longer treatments. 1day treatments are a gamble and 3 day courses are what my doctors have always recommended.

Yes longer treatments are cheaper, but the more stubborn the infection or more often a woman gets these infections, the longer the course of treatment. I used to get yi's chronically, and once took a two one day traetments, then a three day and finally an 8 day. If I'd taken a 5 day in the first place it might have been over quick.

Anyway, I've tried the 1 days several times and never once has it cured the infection. Every one is different.

September 19, 2015 - 6:08am
EmpowHER Guest

From my experience I have always gotten a yeast infection after my periods. I used the Miconozole 1 day treatment, not only did it burn it actually chapped my labia's and cause a tear. It also did not cute my yeast infection. The next day I bought some Tioconozole 1 day treatment. No burning slight itching but the next morning a I had no more symptoms of the infection. I do not understand why anyone would want to treat themselves for a yeast infection 3 or even worse 7 days. If you ate on a budget than I suppose you can buy the lon get treatments but from experience it made me miserable waiting that long.

May 9, 2015 - 9:09pm
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