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Panhypopituitarism Symptoms & Diagnosis


Symptoms arise from:

Compression From Tumor

  • Blurred vision
  • Loss of visual field
  • Poor temperature control

Insufficient Hormones

  • Insufficient levels of gonadotropins
    • In premenopausal women causes: missing menstrual cycles, infertility , osteoporosis , vaginal dryness, as well as loss or reduction in female characteristics
    • In men causes: impotence , reduced size of testes, decreased production of sperm, infertility , breast enlargement, reduced muscle mass, and loss or reduction in male characteristics (eg, beard growth)
  • Insufficient levels of growth hormone
    • In children causes: stunted growth or dwarfism
    • In adults causes: weakness, obesity , reduced cardiac output, low blood sugar levels, and reduced exercise tolerance
  • Insufficient levels of thyroid-stimulating hormones
    • Leads to underactive thyroid , which causes confusion, hair loss, weakness, slow heart rate, muscle stiffness, intolerance to cold, constipation , weight gain, and dry skin
  • Insufficient corticotrophic levels
    • Leads to underactive adrenal gland: causes low blood pressure, low blood sugar , fatigue, weight loss, vomiting, and low stress tolerance
  • Excessive prolactin levels
    • Causes women to have missed periods, infertility, and milk secretion
    • Men causes: reduced facial and body hair and small testes


Your doctor will ask about your symptoms and medical history. A physical exam will be done.

Tests may include the following:

  • MRI scan —a test that uses magnetic waves to make pictures of structures inside the body
  • Blood tests—to measure hormone levels
  • Stimulation tests—to test the reserve of the endocrine glands, especially the pituitary gland
  • Semen analysis—in males suspected of infertility

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