Charcot-Marie-Tooth (CMT) disease is a group of genetic disorders that affects movement and sensation in the limbs. The disease progresses slowly and causes damage to the peripheral nerves that control muscles and transmit sensation.


CMT is caused by defects in specific genes (genetic mutations) often inherited in an autosomal dominant pattern. This means that for some forms of CMT, if one parent has CMT, each child has a 50% chance of inheriting the gene and the disease.

CMT can be classified in a number of ways:

  • Type I (demyelinating)—This type affects the coating of the nerve called the myelin sheath, causing nerve impulses to travel more slowly. It usually occurs in childhood or adolescence and is the most common type of CMT.
  • Type II (axonal)—This type affects the part of the nerve called axons. Although the speed is normal, the size or amount of impulses is less than normal. This type of CMT is less common and occurs after adolescence.
  • Type III—Also called Dejerine-Sottas disease, this is a more rare, severe, early onset form of CMT. It is sometimes considered to be a subtype of CMT Type I. Symptoms may include:
    • Delayed ability to walk due to weakness of the leg muscles closest to the trunk
    • Severe sensory problems
    • Hearing loss
  • Type IV (demyelinating autosomal recessive)—This is similar to Type I, but often less severe. The inheritance pattern also makes it less likely to be inherited by an affected individual's children.

Nerve Cell

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Risk Factors

The primary risk factor for developing CMT is having family members with this disease.


Symptom onset and type vary depending on the type of CMT. Usually, symptoms first appear in children and young adults. The first sign of CMT is often a high arched foot or difficulty walking. Other symptoms may include:

  • Hammer toes]]>
  • High arched heels
  • Decreased sensation in the feet and legs
  • Muscle cramping in legs and forearms
  • Flexed toes
  • Difficulty holding the foot up in a horizontal position
  • Frequent ]]>sprained ankles]]> and ]]>ankle fractures]]>
  • Problems with balance
  • Muscle weakness and atrophy in the lower extremities—can spread to the upper extremities later in life
  • Foot drop
  • Diminished ability to detect hot and cold, vibration, and position
  • Difficulty writing, fastening buttons and zippers, and manipulating small objects
  • ]]>Scoliosis]]>
  • Delay in learning how to walk (Type III)
  • Congenital ]]>glaucoma]]> (Type IV only)



The doctor will ask about your symptoms and medical history, and perform a physical exam. Tests may include:

  • Nerve conduction study]]> —a test that measures the speed and amplitude of nerve impulses in the extremities
  • ]]>Electromyogram (EMG)]]> —a test that records the electrical activity of muscle cells
  • DNA blood test—to confirm certain types of CMT, even if there are no symptoms


Although there is no cure for CMT, treatment may help to improve function, coordination, and mobility. Treatment is also essential to protect against injury due to muscle weakness and diminished sensation. Treatment may include:

  • Physical and occupational therapy
  • Moderate exercise
  • Braces of lower legs
  • Shoe inserts to correct foot deformity
  • Foot care and routine exams with a specialist (podiatrist)
  • Orthopedic surgery


There are no known ways to prevent CMT once a person is born with the condition. If you have CMT or have risk factors, you may want to talk to a genetic counselor before deciding to have children.