Cisplatin is a chemotherapy drug used to treat cancer of the testicles, bladder, lung, stomach, esophagus, and ovaries, as well as other forms of cancer. Cisplatin can cause numerous side effects, including:
- Nausea and vomiting
- Kidney or liver damage
- Peripheral neuropathy (numbness or tingling of the extremities)
- Hearing loss
- Ringing in the ear
- Loss of appetite
- Abnormal taste sensations
- Hair loss
Some of the treatments mentioned below have been advocated for preventing or treating cisplatin side effects. For information on the use of natural treatments as a support to cancer chemotherapy in general, see the ]]>Cancer Treatment]]> article.
Possible Harmful Interaction
The herb black cohosh is often used for menopausal symptoms. Because women receiving cancer chemotherapy may experience menopausal symptoms, black cohosh may appear a promising option. However, one test-tube study found that use of black cohosh may decrease the effectiveness of cisplatin. ]]>1]]>
Possible Helpful Interaction
It has been suggested that many of the undesired effects of cisplatin are due to creation of free radicals, dangerous, naturally occurring substances that can damage many cells. For this reason, treatment with antioxidants has been proposed for preventing toxic side effects. However, as yet there is no more than minimal evidence for benefit.
One animal study tested a combination of substances with strong antioxidant properties ( ]]>vitamin E]]> , Crocus sativus , and Nigella sativa ) and found evidence that this mixture reduced the kidney toxicity of cisplatin.
A small human trial found evidence that use of vitamin E might help prevent nerve injury (peripheral neuropathy) caused by cisplatin, but because this was an ]]>open study]]> , its results are not very reliable. ]]>7]]>
Unfortunately, in open studies, the placebo effect and other confounding factors can play a significant role. (For more information on why this is the case, see ]]>Why Does This Database Rely on Double-blind Studies?)]]>
In a better-designed, ]]>double-blind]]> , placebo-controlled study of 48 people undergoing cancer treatment with cisplatin, participants were given either placebo or a combination of ]]>vitamin E]]> , ]]>vitamin C]]> , and ]]>selenium]]> in hopes of reducing toxicity to the ears and kidneys. ]]>9]]> No significant benefits were seen.
Note that there are concerns that use of antioxidants could potential decrease the effectiveness of some forms of chemotherapy. For this reason, we strongly suggest that people on cancer chemotherapy do not use antioxidants, or any herbs or supplements, except in consultation with their physician.
6. Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer . 1999;35:1688–92.
9. Weijl NI, Elsendoorn TJ, Lentjes EG, et al. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur J Cancer . 2004;40:1713–23.
Last reviewed April 2009 by EBSCO CAM Review Board]]>
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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