(Dry Gangrene; Gas Gangrene; Organ or Tissue Death; Wet Gangrene)
Gangrene is the death of an organ or body tissue. When the blood supply is cut off, the tissue doesn't get enough oxygen and begins to die. If the gangrene is widespread, shock]]> can occur.
There are three main types:
- Dry gangrene—lack of blood supply causes the tissue to dry up and slough off
- Wet gangrene—usually occurs when the tissue is infected with bacteria, tissue becomes moist and breaks down
- Gas gangrene—a particular type of bacteria ( Clostridia ) produces gas bubbles in the tissue
Causes of gangrene include:
These factors increase your chance of developing gangrene. Tell your doctor if you have any of these:
Symptoms may include:
- Pain, followed by numbness when the tissue is dead
- Sloughing off of skin
- Color changes, ranging from white, to red, to black
- Shiny appearance to skin
- Frothy, clear, watery discharge
- Fever and chills
- Nausea and vomiting
Gangrene of the Foot
The doctor will ask about your symptoms and medical history, and perform a physical exam.
Tests may include:
- Blood tests
- Tests of the discharge and the tissue
- X-rays]]> —a test that uses radiation to take pictures of structures inside the body
- ]]>CT scan]]> —a type of x-ray that uses a computer to make pictures of the inside of the body
- ]]>MRI scan]]> —a test that uses magnetic waves to make pictures of the inside of the body
Treatment of gangrene includes:
- Antibiotics—given through an IV in a very potent form
- Blood thinners—given to prevent blood clots
- Debridement]]> —surgical procedure to cut away dead and dying tissue, done to try to avoid gangrene from spreading
- Amputation— removal of severely affected body part (eg, ]]>toe or foot amputation]]> , ]]>above-the-knee amputation]]> )
- ]]>Hyperbaric oxygen treatment]]> —involves exposing the affected tissue to oxygen at high pressure
American Academy of Family Physicians
American Diabetes Association
Canadian Diabetes Association
Cecil RL, Goldman L, Bennett JC. Cecil Textbook of Medicine . 21st ed. Philadelphia, PA: WB Saunders Company; 2000.
Conn HF, Rakel RE. Conn's Current Therapy 2001 . 53rd ed. Philadelphia, PA: WB Saunders Company; 2001.
Gas gangrene. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated June 2008. Accessed June 24, 2008.
Mandell GL, Douglas RG, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases . 5th ed. Philadelphia, PA: Churchill Livingstone; 2000.
Rosen P, et al. Emergency Medicine: Concepts and Clinical Practice . 4th ed. St. Louis, MO: Mosby-Year Book; 2000.
Last reviewed November 2008 by ]]>Ross Zeltser, MD, FAAD]]>
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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