Mitral regurgitation is the leaking of blood from the left ventricle across the mitral valve, and into the left atrium. The flow of blood pumped by the heart is controlled by one-way valves. These valves assure that blood moves in only one direction. When the mitral valve leaks, some of the blood that should be pumped into the body instead goes backward into the left atrium. If the amount of blood that leaks is severe, mitral regurgitation can be a serious condition that requires care from your doctor. The sooner it is treated, the more favorable the outcome. If you suspect you have this condition, contact your doctor immediately.
Function of the Mitral Valve in the Heart
Mitral Valve Regurgitation
There are several causes for leaky heart valves. Birth defects can deform them. Infections can scar them. Heart attacks can damage them, and the mechanics of an enlarged heart can stretch out the opening so that the valve is no longer large enough to work effectively.
- Rheumatic fever]]> —infectious diseases of several kinds can afflict the inside of the heart, leading to scarring of the heart’s valves. Rheumatic fever used to be a common cause of mitral valve damage but is seen infrequently today in the United States.
- ]]>Heart attack]]> —inadequate blood supply to the heart can weaken the small muscles that hold the mitral valve in place, causing it to leak.
- Congenital deformity—several different types of ]]>congenital heart defects]]> distort the mitral valve.
- Heart muscle disease—not only infections, but many other types of disease can weaken the heart muscle, stretching out the mitral valve ring so that the valve no longer closes. Among these causes are alcohol, certain drugs, ]]>radiation]]> , muscular dystrophies, malnutrition, ]]>cancer]]> , and a long list of inflammatory and metabolic disorders.
- Mitral valve prolapse—abnormal closure of the valve with protrusion of a leaflet tip backward into the left atrium, causing it to leak. This may me congenital or acquired.
The following factors increase your chance of developing mitral regurgitation. If you have any of these risk factors, tell your doctor:
- A history of rheumatic fever]]> or other serious infectious disease
- Inflammatory diseases such as lupus and ]]>rheumatoid arthritis]]>
- Storage diseases such as ]]>hemochromatosis]]> and glycogen storage disease
- Heart disease
- Muscle disease
- Radiation exposure
- Exposure to certain drugs (eg, lithium, sulfonamides, ]]>cancer chemotherapy]]> , phenothiazines)
These symptoms may be caused by mitral regurgitation or other serious health conditions. If you experience any one of them, see your physician.
- Chronic, progressive fatigue
- Shortness of breath
- Worsening shortness of breath when you lie down
Your doctor will ask about your symptoms and medical history and perform a physical exam. Leaking heart valves usually make sounds that can be heard through a stethoscope. You will likely be referred to a cardiologist.
Tests may include the following:
Talk with your doctor about the best treatment plan for you. Treatment options include the following:
Treat Underlying Disease
There are several open heart surgical procedures that can fix leaking valves. The type chosen will depend upon the particular nature of the valve.
To help reduce your chance of getting mitral regurgitation, take the following steps:
US National Library of Medicine and the National Institutes of Health
The Merck Manual–Second Home Edition
Canadian Cardiovascular Society
Heart and Stroke Foundation of Canada
Braunwald E. Valvular heart disease. In: Isselbacher K, et al. (Eds). Harrison's Principles of Internal Medicine. 14th ed. New York: McGraw-Hill; 1998.
Wood AJJ. Adverse reactions to drugs. In: Isselbacher K, et al. (Eds.) Harrison's Principles of Internal Medicine . 14th ed. New York: McGraw-Hill; 1998.
Wynne J, Braunwald E. The cardiomyopathies and myocarditides. In: Isselbacher K, et al. (Eds). Harrison's Principles of Internal Medicinem . 14th ed. New York: McGraw-Hill; 1998.
Last reviewed November 2008 by ]]>Michael J. Fucci, DO]]>
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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