Nitrous oxide gas is used primarily as a local anesthetic in dentistry as well as in certain phases of cardiac bypass surgery.


Folate]]> , ]]>Vitamin B12]]>

Supplementation Possibly Helpful

Nitrous oxide can occasionally cause significant vitamin B 12 deficiency especially in people who are already borderline deficient in the vitamin (total vegetarians, for example) or those who are frequently exposed to the gas such as dentists and anesthesiologists. ]]>1–4]]>

The effect on B 12 impacts folate, too. ]]>5,6,7]]>

Taking folate and B 12 supplements at the U.S. Dietary Reference Intake (formerly known as the Recommended Dietary Allowance) levels should prevent any problems from developing.