• Ascorbate, Ascorbic Acid
• ]]>Acute Anterior Uveitis]]>, ]]>Aging Skin]]>, ]]>Allergies]]>, ]]>Asthma]]>, ]]>Autism]]>, Bedsores, Bladder Infections in ]]>Pregnancy]]>, ]]>Cancer (Prevention)]]>, ]]>Cancer (Treatment)]]>, ]]>Cataracts]]>, ]]>Colds (Treatment, Not Prevention)]]>, ]]>Easy Bruising]]>, ]]>Gallbladder Disease (Prevention)]]>, ]]>Glaucoma]]>, ]]>Heart Disease (Prevention)]]>, ]]>HIV Support]]>, ]]>Hypertension]]>, ]]>Insomnia]]>, ]]>Low Sperm Count]]>, ]]>Macular Degeneration]]>, Maintaining Effectiveness of ]]>Nitrate Drugs]]>, ]]>Menopausal Symptoms]]>, ]]>Minor Injuries]]>, ]]>Muscle Soreness after Exercise]]>, ]]>Osteoarthritis]]>, ]]>Photosensitivity]]>, ]]>Preeclampsia (Prevention)]]>, Reflex Sympathetic Dystrophy (RSD) (Prevention), ]]>Sunburn (Prevention)]]>, ]]>Vascular Dementia (Prevention)]]>, ]]>Ulcers]]>, ]]>Weight Loss]]>
Although most animals can make vitamin C from scratch, humans have lost the ability over the course of evolution. We must get it from food, chiefly fresh fruits and vegetables. One of this vitamin's main functions is helping the body manufacture collagen, a key protein in our connective tissues, cartilage, and tendons.
From ancient times through the early nineteenth century, sailors and others deprived of fresh fruits and vegetables developed a disease called scurvy . Scurvy involves so-called scorbutic symptoms, which include nonhealing wounds, bleeding gums, bruising, and overall weakness. Now we know that scurvy is nothing more than vitamin C deficiency.
Scurvy was successfully treated with citrus fruit during the mid-1700s. In 1928, when Albert Szent-Gyorgyi isolated the active ingredient, he called it the anti-scorbutic principle, or ascorbic acid. This, of course, is vitamin C.
Vitamin C is a powerful ]]>antioxidant]]> that neutralizes damaging natural substances called free radicals. It works in water, both inside and outside of cells. Vitamin C complements another antioxidant vitamin, ]]>vitamin E]]> , which works in lipid (fatty) parts of the body.
Vitamin C is the single most popular vitamin supplement in the United States and perhaps the most controversial, as well. In the 1960s, two-time Nobel Prize winner Dr. Linus Pauling claimed that vitamin C could effectively treat both cancer and the common cold. Subsequent research has mostly discounted these claims, but hasn't dampened enthusiasm for this essential nutrient. The vitamin C movement has led to hundreds of clinical studies testing the vitamin on dozens of illnesses; at present, however, no dramatic benefits have been discerned.
Vitamin C is an essential nutrient that must be obtained from food or supplements; the body cannot manufacture it. The official US and Canadian recommendations for daily intake are as follows:
- 0-6 months: 40 mg
- 7-12 months: 50 mg
- 1-3 years: 15 mg
- 4-8 years: 25 mg
- 9-13 years: 45 mg
- 14-18 years: 75 mg
- 19 years and older: 90 mg
- 14-18 years: 65 mg
- 19 years and older: 75 mg
- Pregnant Women
- 18 years old or younger: 80 mg
- 19 years and older: 85 mg
- Nursing Women
- 18 years old or younger: 115 mg
- 19 years and older: 120 mg
Scurvy, the classic vitamin C deficiency disease, is now a rarity in the developed world, although a more subtle deficiency of vitamin C is fairly common. ]]>2-6]]> According to one study, 40% of Americans do not get enough vitamin C. ]]>7]]> In fact, vitamin C deficiency sufficient to cause bleeding problems during surgery turns out to be more common than previously thought. ]]>141]]>
]]>Aspirin]]> and other anti-inflammatory drugs might lower body levels of vitamin C, ]]>8-10]]> as might ]]>oral contraceptives]]> . ]]>11-15]]> Supplementation may be helpful if you are taking any of these medications.
Most of us think of orange juice as the quintessential source of vitamin C, but many vegetables are actually even richer sources. Red chili peppers, sweet peppers, kale, parsley, collard, and turnip greens are full of vitamin C, as are broccoli, Brussel sprouts, watercress, cauliflower, cabbage, and strawberries. (Oranges and other citrus fruits are good sources, too.)
One great advantage of getting vitamin C from foods rather than from supplements is that you will get many other potentially healthful nutrients at the same time, such as bioflavonoids and carotenes. However, vitamin C in food is partially destroyed by cooking and exposure to air, so for maximum nutritional benefit you might want to try freshly made salads rather than dishes that require a lot of cooking.
Vitamin C supplements are available in two forms: ascorbic acid and ascorbate. The latter is less intensely sour.
Ever since Linus Pauling, proponents have recommended taking vitamin C in enormous doses, as high as 20,000 mg to 30,000 mg daily. However, some evidence suggests that there might not be any reason to take more than 200 mg of vitamin C daily (10 to 100 times less than the amount recommended by vitamin C proponents). 16]]> The reason is that if you consume more than 200 mg daily (researchers have tested up to 2,500 mg) your kidneys begin to excrete the excess at a steadily increasing rate, matching the increased dose. Your digestive tract also stops absorbing it well. The net effect is that no matter how much you take, your blood levels of vitamin C don't increase very much.
However, there are some flaws in this research. It is possible that vitamin C levels might rise in other tissues even if they remain constant in the blood. Furthermore, this study did not evaluate the possible effects of taking vitamin C several times daily rather than once daily.
Many nutritional experts recommend a total of 500 mg of vitamin C daily. This dose is almost undoubtedly safe. Others recommend that you take as much vitamin C as you can, up to 30,000 mg daily, cutting back only when you start to develop stomach cramps and diarrhea. This recommendation seems based more on a semi-religious enthusiasm for the vitamin C than on any evidence that such huge doses of the vitamin are good for you.
Intravenous vitamin C can easily raise vitamin C levels to a level 140 times higher than the maximum achievable with oral vitamin C. ]]>152]]> However, there is no meaningful evidence that intravenous vitamin C provides any medical benefits.
According to numerous double-blind, placebo-controlled]]> studies, regular use of vitamin C supplements can slightly reduce symptoms of ]]>colds]]> and modestly shorten the length of the illness. ]]>17,18,146]]> However, taking vitamin C at the onset of a cold probably will not work. ]]>83,140]]>
Regular use of vitamin C does not seem to help prevent colds. ]]>86,146]]> One exception is the “post-marathon sniffle”—colds that develop after heavy exercise. ]]>19,20]]> Vitamin C may be helpful for preventing this condition, although not all studies agree. ]]>153]]>
Two double-blind studies suggest that the use of vitamin C combined with ]]>vitamin E]]> might slightly reduce the risk of developing ]]>preeclampsia]]> , a complication of pregnancy. ]]>21,169]]> However, a much larger follow-up study failed to find benefits. ]]>170]]>
Two studies conducted by a single research group have found that vitamin C at a dose of 500 mg daily might help prevent reflex sympathetic dystrophy, a poorly understood condition that can follow injuries such as fractures. ]]>110,180]]>
Over time, the body develops tolerance to drugs in the nitrate family (such as ]]>nitroglycerin]]> ). Some evidence suggests that use of vitamin C can help maintain the effectiveness of these medications. ]]>142-145]]>
Other small double-blind trials suggest that vitamin C might be helpful for ]]>anterior uveitis]]> (when taken in combination with ]]>vitamin E]]> ), ]]>52]]>]]>autism]]> , ]]>40]]>]]>easy bruising]]> , ]]>29]]>]]>minor injuries]]> , ]]>41]]> protecting the liver in nonalcoholic steatohepatitis, ]]>154]]> speeding recovery from bedsores, ]]>37]]> treating ]]>female infertility]]> (specifically, a condition called "luteal phase defect"), ]]>155]]> and preventing early rupture of the chorioamniotic membranes ("the water breaking") in ]]>pregnancy]]> . ]]>156]]> Vitamin C might also improve the effectiveness of antibiotic treatment for Helicobacter pylori , the cause of most ]]>peptic ulcers]]> . ]]>179]]>
Preliminary evidence suggests that cream containing vitamin C may improve the appearance of ]]>aging or sun-damaged skin]]> . ]]>50,51,157]]> Inconsistent evidence suggests that oral or topical vitamin C, taken by itself or in combination with ]]>vitamin E]]> , may also help protect the skin against sun damage. ]]>42-49]]>
Double-blind studies of vitamin C for the following conditions have yielded mixed results: ]]>asthma]]> , ]]>30, 178]]>]]>male infertility]]> , ]]>38,39]]> reducing the ]]>muscle soreness]]> that typically develops after exercise, ]]>36,176,177]]> and ]]>hypertension]]> . ]]>31-35,147,148]]>Note : Unexpectedly, one study found that a combination of vitamin C (500 mg daily) and grape seed ]]>oligomeric proanthocyanidins (OPCs)]]> (1,000 mg daily) slightly increased blood pressure. ]]>158]]> Whether this was a fluke of statistics or a real combined effect remains unclear.
Limited and in some cases contradictory evidence suggests possible benefit in the prevention or treatment the following conditions:
- Atrial fibrillation following coronary artery bypass grafting (CABG) ]]>182]]>
- Bladder infections during ]]>pregnancy]]>]]>181]]>
- ]]>Gallbladder disease]]> (in women) ]]>53]]>
- General anesthetics ]]>171]]>
- ]]>Vascular dementia]]>]]>54]]>
Intravaginal use of vitamin C tablets might be helpful for non-specific vaginitis. ]]>159]]>
]]>Observational]]> studies indicate that people with a higher intake of vitamin C have a lower incidence of ]]>cataracts]]> , ]]>macular degeneration]]> , ]]>heart disease]]> , ]]>cancer]]> , and ]]>osteoarthritis]]> . ]]>22-27,59-66]]> However, these findings do not indicate that vitamin C supplements will help prevent or treat these conditions. Observational studies are notoriously unreliable for showing the efficacy of treatments; only double-blind studies can do that, and only one has been performed that directly examined vitamin C’s potential benefits for preventing these conditions. (For more information on why double-blind studies are so important, see ]]>Why Does This Database Rely on Double-blind Studies?]]> ) Two large double-blind trials exploring the effectiveness of vitamin C for heart disease prevention—one in women at high risk181 and the other in men at low risk— ]]>183]]> failed to find any benefit at all.
Vitamin C has been proposed as a treatment for cancer, but this claim is very controversial, and there is as yet no scientifically meaningful evidence that it works. ]]>67-70]]>
Massive doses of vitamin C have at times been popular among people with ]]>HIV]]> infection based on highly preliminary evidence. ]]>71,72]]> An observational study linked high doses of vitamin C with slower progression to AIDS. ]]>73]]> However, a double-blind study of 49 people with HIV who took combined vitamins C and E or placebo for 3 months did not show any significant effects on the amount of HIV detected or the number of opportunistic infections. ]]>74]]> Furthermore, one study found that vitamin C at a dose of 1 g daily substantially reduced blood levels of the drug indinavir, a protease inhibitor used for the treatment of HIV infection. ]]>160]]> This could potentially cause the drug to fail.
According to a double-blind, placebo-controlled study of 141 women with ]]>cervical dysplasia]]> (early cervical cancer), vitamin C, taken at a dosage of 500 mg daily, does not help to reverse the dysplasia. ]]>75]]>
What Is the Scientific Evidence for Vitamin C?
As the most famous of all natural treatments for the common cold]]> , vitamin C has been subjected to irresponsible hype from both proponents and opponents. Enthusiasts claim that if you take vitamin C daily, you will never get sick, while critics of the treatment insist that vitamin C has no benefit at all.
However, a cool-headed evaluation of the research indicates something in between. Numerous studies have found that vitamin C supplements taken at a dose of 1,000 mg daily or more throughout the cold season can modestly reduce symptoms of colds and help you get over a cold faster, but they do not generally help prevent colds. ]]>81,83,146,162]]>
Reducing Cold Symptoms
Most studies on vitamin C have evaluated the potential benefits to be gained by taking vitamin C throughout the cold season. The combined results of these trials suggest that use of vitamin C in this way can slightly reduce symptoms and marginally decrease the duration of colds. ]]>81,83]]>
Many people use vitamin C for colds in a different way: they only begin taking it when cold symptoms start. The limited body of evidence available suggests that vitamin C is probably not effective when used in this way. ]]>83,140]]> One double-blind trial enrolled 400 individuals with new-onset cold symptoms, and divided them into four different daily vitamin C dosage groups: 30 mg daily (a dose lower than the minimum daily requirement, and used by the researchers as a placebo), 1,000 mg, 3,000 mg, or 3,000 mg with bioflavonoids. ]]>140]]> Participants were instructed to take the vitamin at the onset of symptoms and for the following 2 days.
The results showed no difference in the duration or severity of cold symptoms among the groups. High-dose vitamin C taken at the onset of a cold, in other words, didn't help. The bottom line: If you want to use vitamin C to take the edge off your colds, take the supplement throughout the winter. (There are numerous other natural treatments for the common cold as well, some of which may be more helpful than vitamin C. For more information, see the full ]]>Colds and Flus]]> article.)
Although two relatively recent studies suggest that regular use of vitamin C throughout the cold season can help prevent colds, ]]>167-168]]> they suffer from a variety of flaws, and most other studies have found little to no benefit along these lines. ]]>146]]>
However, people who are truly vitamin C-deficient, such as elderly people in nursing homes, may show increased resistance to infection if they take vitamin C (or other nutrients). ]]>86]]>
In addition, vitamin C might be helpful for preventing the respiratory infections that can follow heavy endurance exercise. Marathon running and similar forms of exertion can temporarily weaken the immune system, leading to infections. Vitamin C may be helpful. According to a double-blind, placebo-controlled study involving 92 runners, taking 600 mg of vitamin C for 21 days prior to a race, made a significant difference in the incidence of sickness afterwards. ]]>87]]> Within 2 weeks of the race, 68% of the runners taking placebo developed cold symptoms versus only 33% of those taking the vitamin C supplement. As part of the same study, non-runners of similar age and gender to those running were also given vitamin C or placebo. Interestingly, the supplement had no apparent effect on the incidence of upper respiratory infections in this group. Vitamin C seemed to be effective in this capacity only for those who exercised intensively!
Two other studies found that vitamin C could reduce the number of colds experienced by groups of people involved in rigorous exercise in extremely cold environments. ]]>88]]> One study involved 139 children attending a skiing camp in the Swiss Alps, while the other enrolled 56 military men engaged in a training exercise in northern Canada during the winter months. In both cases, the participants took either 1 g of vitamin C or placebo daily at the time their training program began. Cold symptoms were monitored for 1 to 2 weeks following training, and significant differences in favor of vitamin C were found.
However, one very large study of 674 US Marine recruits in basic training found no such benefit. ]]>89]]> The results showed no difference in the number of colds between the treatment and placebo groups.
What's the explanation for this discrepancy? There are many possibilities. Perhaps basic training in the Marines is significantly different from the other forms of exercise studied. Another point to consider is that the Marines didn't start taking vitamin C right at the beginning of training, but waited 3 weeks. The study also lasted a bit longer than the positive studies mentioned above, continuing for 2 months; maybe vitamin C is more effective at preventing colds in the short term. Of course, another possibility is that it doesn't really work. More research is needed to know for sure.
]]>Preeclampsia]]> is a dangerous complication of pregnancy that involves high blood pressure, swelling of the whole body, and improper kidney function. A double-blind, placebo-controlled study of 283 women at increased risk for preeclampsia found that supplementation with vitamin C (1,000 mg daily) and vitamin E (400 IU daily) significantly reduced the chances of developing this disease. ]]>96]]>
While this research is promising, larger studies are necessary to confirm whether vitamins C and E will actually work. The authors of this study point out that similarly sized studies found benefits with other treatments, such as aspirin, that later proved to be ineffective when large-scale studies were performed. Furthermore, keep in mind that we don't know whether such high dosages of these vitamins are absolutely safe for pregnant women.
Cancer treatment is one of the more controversial proposed uses of vitamin C. An early study tested vitamin C in 1,100 terminally ill cancer patients. One hundred patients received 10,000 mg daily of vitamin C, while 1,000 other patients (the control group) received no treatment. Those taking the vitamin survived more than four times longer on average (210 days) than those in the control group (50 days). ]]>102]]> A large (1,826 subjects) follow-up study by the same researchers found a nearly doubled survival rate (343 days versus 180 days) in vitamin C-treated patients whose cancers were deemed "incurable," as compared to untreated controls. ]]>103]]> However, these studies were poorly designed, and other generally better-constructed studies have found no benefit of vitamin C in cancer. ]]>104,105]]> At the present time, vitamin C cannot be regarded as a proven treatment for cancer.
Reflex Sympathetic Dystrophy
Reflex sympathetic dystrophy (RSD) is a set of symptoms that can develop in the legs, arms, feet, and hands after fractures and other injuries. Also called complex regional pain syndrome (CRPS), symptoms include changes in skin temperature and color over the affected area, accompanied by burning pain, sensitivity to touch, sweating, and limitation of range of motion. The cause of RSD is unknown, and the condition is very difficult to treat.
Two studies performed by a single research group reported evidence that vitamin C can help prevent RSD after wrist fractures. ]]>110,180]]>
In one of these, a total of 123 adults with wrist fractures were enrolled and followed for one year. ]]>110]]> All were given 500 mg of vitamin C or placebo daily for 50 days. The results showed significantly fewer cases of RSD in the treated group.
A subsequent study conducted by the same research group compared placebo against three dosages of vitamin C in 416 people suffering from wrist fracture. ]]>180]]> Again, treatment continued for 50 days. The results indicated that approximately 10% of those given placebo developed RSD, while less than 2% of those given either 500 mg or 1,500 mg of vitamin C daily did so. According to the statistical analysis used by the authors, this relative benefit was statistically significant. The 200 mg dose of vitamin C did appear to offer some protection too, but not as much.
Hypertension (High Blood Pressure)
According to a 30-day, double-blind study of 39 individuals taking medications for ]]>hypertension]]> , treatment with 500 mg of vitamin C daily can reduce blood pressure by about 10%. ]]>112]]> Smaller benefits were seen in studies of individuals with normal blood pressure or borderline hypertension. ]]>113,114,148]]> However, other studies have failed to find any significant blood pressure-lowering effect. ]]>115,116,147]]> This mixed evidence suggests, on balance, that if vitamin C does have any blood pressure-lowering effect, it is at most quite small.
Maintaining the Effectiveness of Nitrate Drugs
]]>Nitroglycerin]]> and related nitrate medications are used for the treatment of angina. However, the effectiveness of these medications tends to diminish over time. According to a double-blind study of 48 individuals, use of vitamin C at a dose of 2,000 mg 3 times daily helped maintain the effectiveness of nitroglycerin. ]]>142]]> These findings are supported by other studies as well. ]]>143-145]]>
Note : Angina is too serious a disease for self-treatment. If you have angina, do not take vitamin C (or any other supplement) except on a physician’s advice.
The US government has issued recommendations regarding tolerable upper intake levels (ULs) for vitamin C. The UL can be thought of as the highest daily intake over a prolonged time known to pose no risks to most members of a healthy population. The ULs for vitamin C are as follows:
- 1-3 years: 400 mg
- 4-8 years: 650 mg
- 9-13 years: 1,200 mg
- Males and Females
- 14-18 years: 1,800 mg
- 19 years and older: 2,000 mg
- Pregnant Women
- 18 years old or younger: 1,800 mg
- 19 years and older: 2,000 mg
- Nursing Women
- 18 years old or younger: 1,800 mg
- 19 years and older: 2,000 mg
However, even within the safe intake range for vitamin C, some individuals may develop diarrhea. This side effect will likely go away with continued use of vitamin C, but you might have to cut down your dosage for a while and then gradually build up again.
Concerns have been raised that long-term vitamin C treatment can cause kidney stones]]> . ]]>129,130,163]]> However, in large-scale observational studies, individuals who consume large amounts of vitamin C have shown either no change or a decreased risk of kidney stone formation. ]]>131-133]]> Still, there may be certain individuals who are particularly at risk for vitamin C-induced kidney stones. ]]>134]]> People with a history of kidney stones and those with kidney failure who have a defect in vitamin C or oxalate metabolism should probably restrict vitamin C intake to approximately 100 mg daily. You should also avoid high-dose vitamin C if you have glucose-6-phosphate dehydrogenase deficiency, iron overload, or a history of intestinal surgery.
Vitamin C supplements increase absorption of ]]>iron]]> . ]]>121-128,164]]> Since it isn’t good to get more iron than you need, individuals using iron supplements shouldn’t take vitamin C at the same time except under a physician’s supervision.
One study from the 1970s suggests that very high doses of vitamin C (3 g daily) might increase the levels of ]]>acetaminophen]]> (such as Tylenol) in the body. ]]>135]]> This could potentially put you at higher risk for acetaminophen toxicity. This interaction is probably relatively unimportant when acetaminophen is taken in single doses for pain and fever, or for a few days during a cold. However, if you use acetaminophen daily or have kidney or liver problems, simultaneous use of high-dose vitamin C is probably not advisable.
As noted above, one study found that vitamin C at a dose of 1 g daily substantially reduced blood levels of the drug indinavir, a protease inhibitor used for the treatment of HIV infection. ]]>165]]>
Heated disagreement exists regarding whether it is safe or appropriate to combine antioxidants such as vitamin C with standard chemotherapy drugs. The reasoning behind the concern is that some chemotherapy drugs may work in part by creating free radicals that destroy cancer cells, and antioxidants might interfere with this beneficial effect. ]]>76,166]]> However, there is no good evidence that antioxidants actually interfere with chemotherapy drugs, but there is growing evidence that they do not. ]]>77,79,151]]>
The maximum safe dosages of vitamin C for people with severe liver or kidney disease have not been determined.
Interactions You Should Know About
If you are taking:
- Aspirin]]> , other anti-inflammatory drugs, or ]]>oral contraceptives]]> : You may need more vitamin C.
- ]]>Acetaminophen (eg, Tylenol)]]> : The risk of liver damage from high doses of acetaminophen may be increased if you also take large doses of vitamin C.
- ]]>Warfarin (Coumadin)]]> or ]]>heparin]]> : High-dose vitamin C might reduce their effectiveness.
- ]]>Iron]]> supplements: High-dose vitamin C can cause you to absorb too much iron. This is especially a problem for people with diseases that cause them to store too much iron.
Medications in the
family: Vitamin C may help maintain their effectiveness.
Note : Angina is too serious a disease for self-treatment. If you have angina, do not take vitamin C (or any other supplement) except on a physician’s advice.
- ]]>Protease inhibitors]]> for HIV: High-dose vitamin C may reduce their effectiveness.
- ]]>Cancer chemotherapy]]> : Do not use vitamin C except on physician’s advice.
1. Lykkesfeldt J, Christen S, Wallock LM, et al. Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr. 2000;71:530-536.
19. Peters EM, Goetzsche JM, Grobbelaar B, et al. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993;57:170-174.
39. Rolf C, Cooper TG, Yeung CH, et al. Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study. Hum Reprod. 1999;14:1028-1033.
44. Trevithick JR, Shum DT, Redae S, et al. Reduction of sunburn damage to skin by topical application of vitamin E acetate following exposure to ultraviolet B radiation: effect of delaying application or of reducing concentration of vitamin E acetate applied. Scanning Microsc. 1993;7:1269-1281.
45. Trevithick JR, Xiong H, Lee S, et al. Topical tocopherol acetate reduces post-UVB, sunburn-associated erythema, edema, and skin sensitivity in hairless mice. Arch Biochem Biophys. 1992;296:575-582.
47. Fuchs J, Kern H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med. 1998;25:1006-1012.
49. Fuchs J, Kern H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med. 1998;25:1006-1012.
51. Rougier A, Humbert P, Zahouani H, et al. Clinical and biological effects of topical vitamin C in the treatment of skin aging. Presented at: 2nd World Congress of the International Academy of Cosmetic Dermatology; November 9-11, 2000; Rio de Janeiro, Brazil.
52. van Rooij J, Schwartzenberg SGWS, Mulder PGH, et al. Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients. Br J Ophthalmol. 1999;83:1277-1282.
61. Khaw KT, Bingham S, Welch A, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. Lancet. 2001;357:657-663.
62. Shibata A, Paganini-Hill A, Ross RK, et al. Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer. 1992;66:673-679.
70. Moertel CG, Fleming TR, Creagan ET, et al. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med. 1985;312:137-141.
73. Tang AM, Graham NHM, Kirby AJ, et al. Dietary micronutrient intake and risk of progression to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus type 1 (HIV-1)-infected homosexual men. Am J Epidemiol. 1993;138:937-951.
79. Kurbacher CM, Wagner U, Kolster B, et al. Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett. 1996;103:183-189.
84. Peters EM, Goetzsche JM, Grobbelaar B, et al. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993;57:170-174.
87. Peters EM, Goetzsche JM, Grobbelaar B, et al. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993;57:170-174.
105. Moertel CG, Fleming TR, Creagan ET, et al. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med. 1985;312:137-141.
109. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr. 1996;64:190-196.
130. Traxer O, Adams-Huet B, Pak CY, et al. Risk of calcium oxalate stone formation with ascorbic acid ingestion. Presented at: American Urological Association 2001 Annual Meeting; June 2-7, 2001; Anaheim, CA.
142. Watanabe H, Kakihana M, Ohtsuka S, et al. Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance. J Am Coll Cardiol. 1998;31:1323-1329.
145. McVeigh GE, Hamilton P, Wilson M, et al. Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate. Circulation. 2002;106:208-213.
150. Mavrikakis ME, Lekakis JP, Papamichael CM, et al. Ascorbic acid does not improve endothelium-dependent flow-mediated dilatation of the brachial artery in patients with Raynaud's phenomenon secondary to systemic sclerosis. Int J Vitam Nutr Res. 2003;73:3-7.
157. Humbert PG, Haftek M, Creidi P, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol. 2003;12:237-244.
158. Ward NC, Hodgson JM, Croft KD, et al. Effects of vitamin C and grape-seed polyphenols on blood pressure in treated hypertensive individuals: results of a randomised double blind, placebo-controlled trial. Asia Pac J Clin Nutr. 2003;12(suppl):S18.
159. Petersen EE, Magnani P. Efficacy and safety of vitamin C vaginal tablets in the treatment of non-specific vaginitis; A randomised, double blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol. 2004;117:70-75.
160. Slain D, Ansden J, Khakoo R, et al. Effects of high-dose vitamin C on the steady state pharmacokinetics of the protease inhibitor Indinavir in healthy volunteers. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting; Sept 13-17, 2003; Chicago, IL. Poster A-1610.
165. Slain D, Ansden J, Khakoo R, et al. Effects of high-dose vitamin C on the steady state pharmacokinetics of the protease inhibitor Indinavir in healthy volunteers. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting; Sept 13-17, 2003; Chicago, IL. Poster A-1610.
172. Huang HY, Appel LJ, Choi MJ, et al. The effects of vitamin C supplementation on serum concentrations of uric acid: Results of a randomized controlled trial. Arthritis Rheum. 2005 Jun 2. [Epub ahead of print]
173. Johnston CS, Corte C, Swan PD. Marginal vitamin C status is associated with reduced fat oxidation during submaximal exercise in young adults. Nutr Metab (Lond). 2006 Aug 31. [Epub ahead of print]
176. Bryer SC, Goldfarb AH. Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. Int J Sport Nutr Exerc Metab. 2006;16:270-280.
178. Tecklenburg SL, Mickleborough TD, Fly AD, et al. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med. 2007 Apr 4. [Epub ahead of print]
179. Chuang CH, Sheu BS, Kao AW, et al. Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. Hepatogastroenterology. 2007;54:320-324.
180. Zollinger PE, Tuinebreijer WE, Breederveld RS, et al. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am. 2007;89:1424-1431.
181. Cook NR, Albert CM, Gaziano JM, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med. 2007;167:1610-1618.
182. Eslami M, Badkoubeh RS, Mousavi M, et al. Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary artery bypass grafting. Tex Heart Inst J. 2007;34:268-274.
183. Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008;300:2123-2133.
Last reviewed April 2009 by EBSCO CAM Medical Review Board]]>
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