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Proton Pump Inhibitor Drugs (PPIs) Cause Low Magnesium Levels

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The mechanism responsible for hypomagnesemia associated with long term PPI use is unknown; however, long term use of PPIs may be associated with changes in intestinal absorption of magnesium.

Patients taking PPIs should seek immediate medical attention if they develop arrhythmias, tetany, tremors or seizures. Doctors should consider testing patients' magnesium levels before prescribing PPIs.

Source: Jennifer Shepherd, Pharmacist, Division of Drug Information, FDA.

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