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What Are the Differences Between MS and Guillain-Barré Syndrome?

By HERWriter
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Differences Between MS and Guillain-Barré Syndrome vitstudio/Fotolia

Multiple sclerosis and Guillain-Barré syndrome are both autoimmune diseases where the protective myelin coverings of the nerves are attacked by one’s own immune system. Both conditions are considered inflammatory demyelinating diseases of the nervous system.

The causes for both are unknown. While there are treatments for both, there is also no cure for either disease.

They differ in that MS affects the nerves of the brain and spinal cord, which is the central nervous system. Lesions are scattered throughout areas in the brain and often affect the optic nerve causing impaired vision.

Guillain-Barré is the result of an attack on the peripheral nervous system by cells located near the peripheral nerve roots. The onset of Guillain-Barré is dramatic, with rapid demyelinating nerve impairment occurring within hours or days of being affected.

Who is affected:

MS occurs in 40-100 people out of 100,000 and in mostly Caucasian populations. Only one-tenth of those affected are Japanese.(2)

MS is uncommon in children under the age of 10 and mostly appears in those aged 20 to 55. Women are more often affected than men.(4)

Guillain-Barré is more rare. According to the National Institute of Neurological Disorders and Stroke only 1 in 100,000 people have the disorder. It can affect people of any age and affects men and women equally. (3)

How it develops and the symptoms:

MS symptoms may occur gradually, or develop then disappear, making it difficult to determine what is causing them.

Optic neuritis is a common first symptom as are impairments in speech, walking and memory. Patients may report difficulty with the bowel, bladder and sexual function.

There are four types of MS. The most common type is relapsing-remitting MS where the symptoms flare up and improve, unpredictably, for years.

Guillain-Barré is often preceded by a viral or bacterial infection, and its onset is sudden and serious.

1) Chapter 23 - Demyelinating diseases of the nervous system.  Dartmouth Medical School.  Retrieved March 13, 2016.

2) F. Yoshi and Y. Shinohara. Autoimmune Neurological Diseases. Journal of the Japan Medical Association (Vol. 129, No. 7, 2003, pages 921–925). Retrieved March 13, 2016.

3) Guillain-Barré Syndrome Fact Sheet. National Institute of Neurological Disorders and Stroke. Retrieved March 13, 2016.

4) What Are the 4 Types of Multiple Sclerosis? EmpowHer.  Retrieved March 13, 2016

5) Multiple Sclerosis Treatment.  Mayo clinic.org. Retrieved March 13, 2016.

Add a Comment4 Comments

EmpowHER Guest

You did not mention CIDP the acute version of GBS. I was diagnosed with GBS. Many family members researched it and thought that they were now experts on the disease. They told me most people are cured of it. Little did I know that I would later be diagnosed with CIDP. I continue to get Ivig every three weeks. I am 4 and 1/2 years into this. No end in sight with the IVIG. My aunts don't get it and think that somehow I am exaggerating my health situation. Wish this article mentioned CIDP.

March 23, 2016 - 9:07pm
HERWriter (reply to Anonymous)

Hi Anon,

I just tried to do some research on CIDP and there actually is not a lot to find. Sorry your family is not more supportive.

I am pasting this from WebMD below to that readers know what CIDP is.  Even in their description, it sounds like most people improve but it takes longer.  I hope you improve with more time. 

take care,


CIDP is sometimes thought of as the chronic form of acute inflammatory demyelinating polyneuropathy (AIDP), the most common form of Guillain Barré syndrome (GBS), in the United States and Europe. In contrast to GBS, most patients with CIDP cannot identify a preceding viral or infectious illness. GBS is a subacute disorder that progresses over 3-4 weeks, then plateaus and usually improves over months and does not recur. CIDP, by definition has ongoing symptoms for over 8 weeks and usually does not improve unless ongoing treatment is given.

March 24, 2016 - 6:26am
EmpowHER Guest

Thank you for this. I have the axonal version of GBS and this article will help me explain it to my friends

March 21, 2016 - 3:51pm
HERWriter (reply to Anonymous)

Glad you found it helpful.  

take care,


March 22, 2016 - 7:23am
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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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