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Pristiq, is taking 2 50mg the same as 1 100mg??

By December 17, 2009 - 6:18pm
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I have been taking Pristiq since last summer. I get good, results, not perfect.... but now with the holidays and the dark winter etc. I feel it is not working as well as it was. My doctor agreed to up the dosage from 50 mg to 100mg. My question is whether I can take 2 of the 50's since I have so many left or do I have to take 100 mg tablets?
I started out on Prozac in the mid eighties and I thought it was a miracle. After 20 years I noticed I felt all the symptoms of depression again. Since then I have gone to several doctors and have taken, most all the meds there is for depression. None have worked that well. Pristiq is the best so far. I also have fairly high chloresterol and have read on the Pristiq website that it does affect chloresterol in some people. I feel for anyone who suffers from depression. It is so hard to find the right treatment, and so many of us do not have insurance. If I did I would also like to see a mental health doctor, but that is impossible. I love this site and all the information that is available.

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Expert HERWriter Guide Blogger

Hi krazig - Thanks for writing to us, and for your compliments about the site. We think it's pretty special too.

You want to know if two 50 mg Pristiq tablets would be equal to one 100 mg tablet, and if it would be safe to take two 50 mg tablets since you have some on hand. Yes, two of the 50 mg tablets would equal 100 mg and, since your doctor has told you that would be a safe dosage for you, you could take two tablets.

Please be aware, however, that the manufacturer, Wyeth, provides the following information on the product website for healthcare professionals:
The recommended dose for PRISTIQ is 50 mg once daily, with or without food. In clinical studies, doses of 50‑400 mg/day were shown to be effective, although no additional benefit was demonstrated at doses greater than 50 mg/day, and adverse events and discontinuations were more frequent at higher doses.

The website has a lot of information that you may find helpful, including a Learning Center and a Patient Education and Support section. The site can be found at:


The company also provides a site for patients. That site can be found here:


It's good to know that you're now doing so well. As with any medication, the more you know, the better. I hope these references are helpful. If you have any additional questions just let us know, and I hope you'll keep us posted on your results and progress with Pristiq.

Take good care,

December 17, 2009 - 6:50pm
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