Chronic granulomatous disease develops when a specific gene from both parent passes to the child. This gene causes abnormal cells to develop in the immune system. The abnormal cells are called phagocytic cells. They normally kill bacteria. With this disease, these cells are impaired. As a result, the body can not fight some types of bacteria. It also makes infections likely to recur.
The increased risk of infections can lead to premature death. Repeated lung infections are often the cause of death with this disease. Preventative care and treatment, can help to reduce and temporarily control infections.
CGD is a rare condition, occurring in about one in 200,000 births in the US.
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