Paget's disease is caused by a malfunction in bone formation. Normally, bones are constantly being broken down by cells called osteoclasts, and rebuilt by cells called osteoblasts. With Paget's disease, bones are broken down abnormally fast, and new bone replacement is loose and bulky, instead of strong and compact. These poorly formed bones may become weak, and may bend over time.
Normal Bone Structure
The exact cause of this bone malformation is unknown, but it is associated with heredity. Some experts believe that Paget's may be triggered early in life by a viral infection.
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