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Paget's Disease Causes & Risks


Paget's disease is caused by a malfunction in bone formation. Normally, bones are constantly being broken down by cells called osteoclasts, and rebuilt by cells called osteoblasts. With Paget's disease, bones are broken down abnormally fast, and new bone replacement is loose and bulky, instead of strong and compact. These poorly formed bones may become weak, and may bend over time.

Normal Bone Structure

Bone Matrix
© 2008 Nucleus Medical Art, Inc.

The exact cause of this bone malformation is unknown, but it is associated with heredity. Some experts believe that Paget's may be triggered early in life by a viral infection.

Risk Factors

A risk factor is something that increases your chance of getting a disease or condition. Risk factors for Paget's disease include:

  • Family history of Paget's disease, especially in a parent, sibling, or child
  • Race: Anglo-Saxon, European
  • Age: 40 or older
  • In US, residence in northern states

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. Copyright © 2023 EBSCO Publishing All rights reserved.

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