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Color Blindness Treatment in the Works

By HERWriter
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Color Blindness Treatment in Development Stuart Miles/PhotoSpin

Color blindness affects 8 percent of males and 0.5 percent of females, or approximately 10 million people in the United States. So says Avalanche Biotechnologies, a biotech firm that strives to develop gene therapies that will treat patients with sight-threatening ophthalmic diseases.

Avalanche Biotechnologies, located in Menlo Park, California, has teamed up with University of Washington “to develop products for the treatment of color vision deficiency (CVD), commonly known as red-green color blindness,” reported a news release on the company’s website.

Drs. Jay and Maureen Neitz, are husband-and-wife scientists at University of Washington who run a color vision lab at the University that studies the mechanism of color vision.

In 2009, the researchers successfully devised a technique to inject a gene that detects red color behind the retina of two male squirrel monkeys. The gene was placed inside a virus to permit its transport. Male monkeys are the perfect test models for humans as they are red-green color blind genetically from birth.

The procedure was successful. It did require surgery on the retina, which is too risky to perform on humans.

The Neitz team has been working for years to find a safe way to apply this technique to humans. With the help of Avalanche, they have been able to use an adeno-associated virus (one that does not cause disease) to contain the vision pigment gene. It can then be injected directly into the vitreous fluid, which is the jelly-like substance that fills the center of the eye.

“It’s a protein shell, kind of like a Trojan horse, that gets you entry into the cell. Once you’re there, the DNA gets to set up shop and produce the photo pigment of interest,” said Thomas W. Chalberg Jr., Ph.D., the co-founder and chief executive of Avalanche to the Seattle Times.

Color blindness can have life-changing effects on people.

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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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