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How Goodpasture's Syndrome Affects the Lungs

By HERWriter
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What is Goodpasture's Syndrome

Goodpasture's Syndrome is a rare autoimmune disorder that affects the lungs and the kidneys. It is also known by the names anti-glomerular basement antibody disease and anti-glomerular basement membrane disease (or anti-GBM disease).

Normally, the body's immune system produces antibodies that fight off infection and illness. With an autoimmune disease such as Goodpasture's Syndrome, the body's antibodies actually attack healthy cells. In the case of Goodpasture's Syndrome, the antibodies attack the lungs and kidneys. Researchers still don't know why.

Specifically, the antibodies attack the alveoli (air sacs) and capillaries of the lungs, and the filtering apparatus of the kidneys. The body reacts to the antibodies by swelling and producing inflammation. This inflammation interferes with normal lung and kidney function.

Research has shown that certain people are genetically predisposed to producing these attacking antibodies. Under certain conditions such as exposure to tobacco smoke, inhalation of gasoline or paint fumes, or the presence of a viral upper respiratory infection, the body will produce antibodies that will not only attack the infection, but also healthy cells.

In Europe it is estimated that one in every millionth person is diagnosed with Goodpasture's Syndrome in a year, primarily in white populations. It is even more rare in other races. Cases have been reported in patients from four to 80 years old, but it is most common in people between 18 to 30 and 50 to 65 years old.

Symptoms of Goodpasture's Syndrome

Over time the lungs (and kidneys) will start to bleed or hemorrhage. While there are other conditions that produce this particular symptom, a Goodpasture's Syndrome diagnosis is usually reserved "when the immune system attacks a particular molecule that is found in the kidney and the lung" known as the Goodpasture antigen.

Usually the lung symptoms will appear before the kidney symptoms. Those symptoms include:

- coughing up blood
- burning sensation when urinating
- fatigue
- nausea
- difficulty breathing
- pale coloring
- blood in the urine

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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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