Benign Prostatic Hyperplasia
• Prostate Enlargement
• ]]>Beta-Sitosterol]]>, ]]>Grass Pollen]]>, ]]>Nettle Root]]>, ]]>Pygeum]]>, ]]>Saw Palmetto]]>
• ]]>Antioxidants]]>, Bixa orellana (Annatto) , ]]>Flaxseed]]>, ]]>Flaxseed Oil]]>, ]]>Green Tea]]>, ]]>Maca]]>, ]]>Oat Straw]]>, ]]>Pumpkin Seeds]]>, ]]>Zinc]]>
If you're a man and you live long enough, you will almost certainly develop benign prostatic hyperplasia (BPH). Ninety percent of all men show signs of such prostatic enlargement by the age of 80. Symptoms include difficulty in starting urination, a diminished force of urinary stream, a sensation of fullness in the bladder after urination, and the need to urinate many times at night. Ultimately, the obstruction can become so severe that urination is impossible.
The most common treatment for BPH is surgery that removes most of the prostate gland. Medications such as Cardura, Flomax, Hytrin, and Proscar can relieve symptoms of BPH. In addition, Proscar has been shown to shrink the prostate and reduce the need for surgery. However, all of these medications can cause significant side effects.
Principal Proposed Natural Treatments
Men who suspect they may suffer from BPH should make sure to see a physician to rule out prostate cancer. After this has been done, many natural options are available that have good scientific backing. Indeed, there are few other conditions for which so many natural therapies have good supporting evidence for efficacy. However, there is one potential advantage for standard medications: some have been shown sufficiently effective at slowing the progression of BPH to help men avoid surgery, while this has not been shown to be true of any natural options. 60]]>
The best-documented herbal treatment for BPH is the oil of the berry of the saw palmetto tree. This herb is so well accepted in Europe that synthetic pharmaceuticals are considered alternative therapy for BPH. Saw palmetto offers two potential advantages over conventional drug treatment. The most obvious is that it usually causes no side effects. Another advantage is that saw palmetto does not change protein-specific antigen (PSA) levels. Lab tests that measure PSA are used to screen for prostate cancer. The widely used drug Proscar can artificially lower PSA levels, which may have the unintended effect of masking prostate cancer.
The scientific evidence that saw palmetto is effective for prostate enlargement is impressive, although not perfect.
At least 10 ]]>double-blind, placebo-controlled]]> studies involving a total of about 900 participants have compared the benefits of saw palmetto against placebo over a period of 1 to 12 months. ]]>2-8,58,61-62]]> In all but 3 of these studies, the herb significantly improved urinary flow rate and most other measures of prostate disease. However, in the most recent and perhaps best-designed of these studies, a 1-year trial of 225 men, saw palmetto product failed to prove more effective than placebo. ]]>63]]>
A double-blind study followed 1,098 men who received either saw palmetto or the drug Proscar over a period of 6 months. ]]>9]]> According to the results, the two treatments were about equally successful at reducing noticeable symptoms, and neither produced much in the way of side effects. However, Proscar lowered PSA levels, presenting a risk of masking prostate cancer. Saw palmetto did not cause this problem. On the other hand, careful measurements showed that Proscar caused men's prostates to shrink by 18%, while saw palmetto only caused a 6% decrease in size. Although prostate size does not correlate well with severity of symptoms, such a decrease in size might indicate a reduced likelihood of need for surgery. This is a potential advantage for the drug.
A 52-week, double-blind study of 811 men compared saw palmetto to a standard drug for BPH in another class: the alpha-blocker tamsulosin. ]]>10]]> Once again, both treatments proved equally effective. However, saw palmetto caused fewer side effects than the drug. In addition, the herb caused some prostate shrinkage, while the drug allowed a slight prostate enlargement.
Although there are many theories about how saw palmetto works, none have been conclusively established. The best evidence suggests that the herb affects male hormones.
For important dosage and safety information, see the full ]]>Saw Palmetto]]> article.
The pygeum tree is a tall evergreen native to central and southern Africa. Its bark has been used since ancient times for urinary problems.
At least 17 double-blind trials, ranging in length from 45 to 90 days, of pygeum for BPH have been performed, involving a total of almost 1,000 individuals. ]]>18-22,57]]> Many of these studies were poorly reported and/or designed. Nonetheless, overall, the results do suggest that pygeum can reduce symptoms such as nighttime urination, urinary frequency, and residual urine volume.
The best of these trials was conducted at 8 sites in Europe and included 263 men between 50 to 85 years of age. ]]>23]]> Participants received 50 mg of a pygeum extract or placebo twice daily. The results showed significant improvements in various measures of BPH severity.
We don't really know how pygeum works. Unlike the standard drug finasteride, it does not appear to work by affecting the conversion of testosterone to dihydrotestosterone. ]]>24]]> Rather, it is thought to reduce inflammation in the prostate and to inhibit prostate growth factors, substances implicated in inappropriate prostate enlargement. ]]>25,26,27]]> We don't know whether pygeum can reduce the need for prostate surgery or whether it affects PSA levels.
For more information, including dosage and safety issues, see the full ]]>Pygeum]]> article.
Anyone who lives in a locale where nettle grows wild will likely discover the powers of this dark green plant. Depending on the species, the fine hairs on its leaves and stem cause burning pain that lasts from hours to weeks. Both its leaves and roots can be used as medicine. The root is a popular European treatment for BPH. However, it has not been as well studied as saw palmetto or pygeum.
In a ]]>double-blind, placebo-controlled study]]> performed in Iran, 558 people were given either placebo or nettle root for 6 months. ]]>64]]> The results indicated that nettle root is significantly more effective than placebo on all major measures of BPH severity. Benefits were seen in three other double-blind studies as well, enrolling a total of more than 150 men. ]]>32-34]]>
For more information, including dosage and safety issues, see the full ]]>Nettle]]> article.
Numerous plants contain cholesterol-like compounds called sitosterols and their close relatives sitosterolins. A special mixture of these, called beta-sitosterol, is used for the treatment of BPH.
A review of the literature, published in 1999, found a total of four randomized double-blind, placebo-controlled studies on beta-sitosterol for BPH, enrolling a total of 519 men. ]]>37-40]]> All but one of these studies found significant benefits in both perceived symptoms and objective measurements, such as urine flow rate. The largest trial followed 200 men with BPH for a period of 6 months. ]]>41]]> After the study was completed, many of the participants were followed for an additional year, during which the benefits continued. ]]>42]]> Similar results were seen in a 6-month, double-blind trial of 177 individuals with BPH. ]]>43]]>
For more information, including dosage and safety issues, see the full ]]>Beta-sitosterol]]> article.
Grass pollen is also used to treat BPH. The grasses used for this preparation are 92% rye, 5% timothy, and 3% corn. Related grass pollen extracts are used for allergy shots. However, the grass pollen extracts described here are different in that they have their allergenic components removed. Grass pollen is also an entirely different product than bee pollen.
Two double-blind, placebo-controlled studies found that grass pollen extract can improve symptoms of prostate enlargement. ]]>45,46]]> There have also been ]]>open studies]]> that compared grass pollen to different treatments for BPH. ]]>47,48]]>
In the first double-blind, placebo-controlled study, 103 individuals with BPH were assigned to take either placebo or 2 capsules of a standardized grass pollen extract 3 times daily for a period of 12 weeks. ]]>49]]> At the end of the study, 69% of the participants who had been taking the grass pollen had reduced the number of trips they had to make to the bathroom at night. In the placebo group, only 37% reported improvement in this symptom. The amount of urine remaining in the bladder following urination was reduced in the treatment group by 24 ml and by 4 ml for the placebo group. Both of these were statistically significant improvements for those taking grass pollen.
The second double-blind, placebo-controlled study lasted longer but enrolled fewer participants. ]]>50]]> Fifty-seven men with prostate enlargement were enrolled in the study, with 31 taking 92 mg of the grass pollen extract daily for 6 months and the remaining 26 taking placebo. As with the previous study, statistically significant improvements in nighttime frequency of urination and emptying of the bladder were found with use of grass pollen extract. Additionally, 69% of the participants receiving treatment reported overall improvement, while only 29% of the group taking the placebo felt they had improved, another ]]>statistically significant]]> difference.
An important finding in this study was that the prostates of the men taking grass pollen significantly decreased in size according to ultrasound measurements taken.
No one is certain how the grass pollen extract causes the beneficial results seen in the studies. One theory is that it inhibits the body's manufacturing of prostaglandins and leukotrienes, which might relieve prostate congestion by reducing inflammation. ]]>51]]>
For more information, including dosage and safety issues, see the full ]]>Grass Pollen Extract]]> article.
A 48-week, double-blind trial of 543 men with early BPH compared combined saw palmetto and nettle root against Proscar and found equal benefits. ]]>55]]> The same combination proved superior to placebo in a 24-week, double-blind study of 257 men. ]]>65]]>
In a 3-month, double-blind, placebo-controlled study of 144 men with BPS, use of a combination product containing saw palmetto, grass pollen extract, beta-sitosterol, and ]]>vitamin E]]> significantly reduced symptoms. ]]>59]]>
A 6-month, double-blind, placebo-controlled trial of 44 men given a saw palmetto herbal blend (containing, in addition, nettle root and pumpkin seed oil) found shrinkage in prostate tissue. ]]>56]]> No significant improvement in symptoms was seen, but the authors pointed out that the study size was too small to statistically detect such improvements if they did occur. Another small study failed to find significant benefit with a combination of pygeum and nettle root. ]]>66]]>
Other Proposed Natural Treatments
]]>Pumpkin seeds]]> are approved for use in BPH by Germany's Commission E. The mineral ]]>zinc]]> is also commonly recommended in both Europe and the United States as a treatment for prostate disease, as are both whole ]]>flaxseed]]> and ]]>flaxseed oil]]> , along with the herbs ]]>maca]]> ( Lepidium meyenii ) and ]]>oat straw]]> ( Avena sativa ). However, there is no meaningful evidence to indicate that any of these proposed options are effective.
In large study investigating the influence of dietary patterns and supplement use on the risk of BPH, researchers followed 4,770 men, initially with normal-sized prostates, for 7 years. They found that ]]>antioxidants]]> supplements did not significantly reduce BPH risk and that ]]>lycopene]]> , ]]>zinc]]> , and ]]>vitamin D]]> supplementation had only a modest beneficial effect. ]]>69]]>
In a 12-month, double-blind, placebo-controlled study of 136 men with benign prostatic hyperplasia of moderate severity, use of Bixa orellana (annatto) at a dose of 250 mg 3 times daily failed to improve symptoms. ]]>68]]>
In a preliminary, double-blind trial of 78 older men, flaxseed extract modestly improved the urinary symptoms associated with ]]>benign prostatic hyperplasia]]> (prostate enlargement) after four months of treatment. ]]>70]]>
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4. Tasca A, Barulli M, Cavazzana A, et al. Treatment of obstructive symptomology caused by prostatic adenoma using an extract of Serenoa repens. Double-blind clinical study vs. placebo [in Italian; English abstract]. Minerva Urol Nefrol. 1985;37:87-91.
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40. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995;345:1529-1532.
41. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995;345:1529-1532.
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45. Becker H, Ebeling L. Conservative therapy of benign prostate hyperplasia (BPH) with Cernilton®N. Results of a placebo-controlled double-blind study [translated from German]. Urologe [B]. 1988;28:301-306.
46. Buck AC, Cox R, Rees RWM, et al. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, Cernilton: a double-blind, placebo-controlled study. Br J Urol. 1990;66:398-404.
47. Maekawa M, Kishimoto T, Yasumoto R, et al. Clinical evaluation of Cernilton on benign prostatic hypertrophy-a multiple center double-blind study with Paraprost [in Japanese; English abstract]. Hinyokika Kiyo. 1990;36:495-516.
49. Becker H, Ebeling L. Conservative therapy of benign prostate hyperplasia (BPH) with Cernilton® N. Results of a placebo-controlled double-blind study [translated from German]. Urologe [B]. 1988;28:301-306.
50. Buck AC, Cox R, Rees RWM, et al. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, Cernilton: a double-blind, placebo-controlled study. Br J Urol. 1990;66:398-404.
59. Preuss HG, Marcusen C, Regan J, et al. Randomized trial of a combination of natural products (cernitin, Saw Palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH). Int Urol Nephrol. 2001;33:217-225.
60. McConnell JD, Roehrborn CG, Bautista OM, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349:2387-2398.
65. Lopatkin N, Sivkov A, Walther C, et al. Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms: a placebo-controlled, double-blind, multicenter trial. World J Urol. 2005 Jun 1. [Epub ahead of print].
66. Melo EA, Bertero EB, Rios LA, et al. Evaluating the efficiency of a combination of pygeum africanum and stinging nettle (urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial. Int Braz J Urol. 2005;28:418-425.
67. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study. Cancer Res. 2006;66:1234-1240.
68. Zegarra L, Vaisberg A, Loza C, et al. Double-blind randomized placebo-controlled study of Bixa orellana in patients with lower urinary tract symptoms associated to benign prostatic hyperplasia. Int Braz J Urol. 2007;33:493-501.
Last reviewed April 2009 by EBSCO CAM Review Board]]>
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