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Clinical Trials for Drug That Will Treat A Double Chin

By HERWriter
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drug trials for treatment of double chin Auremar/PhotoSpin

Thinking about how to get rid of that double chin? You are not alone.

Bayer Healthcare along with California-based Kythera Biopharmaceuticals have begun the third round of clinical trials to test a drug called ATX-101 that targets fat cells deposited under the chin. This area is called SMF or submental fat.

Currently, liposuction is the procedure used for removal of fatty deposits under the chin but the procedure can have some adverse effects.

A few years ago a drug called Lipodissolve was promoted as a “lunchtime lipo” alternative. It contained two chemicals, phosphatidylcholine (PC) and deoxycholate (DC).

However neither of these drugs were approved by the FDA for fat elimination.

ATX-101 is just sodium deoxycholate (DC in solution) in synthetic form, which acts like human bile and which causes dietary fat to degrade.

Deoxycholate is actually a common ingredient in soap. It behaves in the body the same way as it does in the wash, where it dissolves grease and oil from your clothes, said abcNews.com.

The most recent trial involved 732 patients from Europe. Kythera is in the process of carrying out another phase III trial in the United States and Canada with findings expected to be available later this year.

The results of two placebo-controlled studies already performed were very positive. Bayer Healthcare reported, “Significant improvements in clinician-reported measurements of SMF, supported by objective caliper measurements of SMF thickness.”

During the trials, the drug was administered monthly for four months and follow-up was performed for an additional three months. Adverse reactions included injection site pain, swelling, bruising and numbness according to Bayer, as reported to Medpagetoday.com.

Dr. Barry Eppley, a plastic/cosmetic surgeon in Indiana, believes the FDA will approve it in the next few years.

Concerns about the use of this new drug were expressed to abcNews.com by Dr. Darrick Antell, a plastic surgeon at Roosevelt Hospital in New York and a spokesman for the American Society of Plastic Surgeons.

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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.