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I am 63 and have been on a cream form of BioIdenticals in the past. This January, I went to a Doctor for my exam and talked about Sotta Pellets. I had them implanted, felt more energized immediately, but had very very tender breasts, to the point of being uncomfortable. I figured things would mellow out, so I tried to ignore it. I did feel more sexually alive. Then, about 5 weeks later, I started to have clots of blood appear. I bled enough to wear a pad day and night. I had not had any bleeding for 14 years. The bleeding lasted for about 6 weeks straight. It was a drag. The bleeding has stopped now, but the breasts are still somewhat tender. I also have been very bloated and somewhat stomach queasy and have gained some weight. I had my hormones checked before we implanted them. I eat healthy, stay active, and am now considering just going off these pellets. I have read through many of the comments here from other women, and agree that you have to weigh out what is acceptable and unacceptable for each of us. For now, I am going au natural.