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I'm getting ready to take my 2nd of 3 shots (stretching over 9 months) of lupron, to treat severe endometriosis with severe pain and mainly, infertility. I've been through fertility treatments and none of them have worked. I've experienced very frequent hot flashes and sweating (I use my husbands deoderant now), and some abdominal cramping and fullness, but thats about it. My pain and symptoms really increased the first 2 months after the first shot, but seemed to have toned down to the point I can work without interference. I am an L&D nurse. I'm now functioning without pain meds, which i was on for several months. I am hoping to finish my rounds in January and start trying for a baby. My doctor told me that once i delivery my baby, provided I do not want more children, my endometriosis is so severe I have to have a hysterectomy. I'm ok with this as long as i get my baby. The side effects are worth it as long as you have a doctor that believes the pain you are in and is willing to work with you. This is the only avenue i have left to conceive...wish me luck and send prayers.