Read about the potential adverse effect of nitrous oxide on ASD children with the MTHFR gene deletion and/or deficiency of Vitamin B-12 (cobalamin).
"Severe Methylenetetrahydrofolate Reductase Deficiency, Methionine Synthase, and Nitrous Oxide — A Cautionary Tale" by Richard W. Erbe, M.D., and Robbert J. Salis, M.D., New England Journal of Medicine, Volume 349:5-6 July 3, 2003 Number 1.
"Adverse Effect of Nitrous Oxide in a Child with 5,10-Methylenetetrahydrofolate Reductase Deficiency" by Rebecca R. Selzer, Ph.D., David S. Rosenblatt, M.D., Renata Laxova, M.D., and Kirk Hogan, M.D., J.D., New England Journal of Medicine, 349;1, July 3, 2003.
A letter in Arch Dis Child 2001;85:510 (December) from Isabel Smith, Clinical Audit Department, Great Ormond Street Hospital in London states: "Nitrous oxide inactivates cobalamin, the active derivative of vitamin B12 and essential cofactor for the transfer of the methyl group from methyltetrahydrofolate to homocysteine to form methionine. For subjects with good body stores of cobalamin this effect is unimportant, but no-one using this agent should remain unaware of the potentially devastating complications in the nervous system of using nitrous oxide in subjects who are of borderline or deficient vitamin B12 status. Onset of subacute combined degeneration affecting the brain and spinal cord is a well documented event when individuals with low body stores of cobalamin are exposed to nitrous oxide."
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Read about the potential adverse effect of nitrous oxide on ASD children with the MTHFR gene deletion and/or deficiency of Vitamin B-12 (cobalamin).
"Severe Methylenetetrahydrofolate Reductase Deficiency, Methionine Synthase, and Nitrous Oxide — A Cautionary Tale" by Richard W. Erbe, M.D., and Robbert J. Salis, M.D., New England Journal of Medicine, Volume 349:5-6 July 3, 2003 Number 1.
"Adverse Effect of Nitrous Oxide in a Child with 5,10-Methylenetetrahydrofolate Reductase Deficiency" by Rebecca R. Selzer, Ph.D., David S. Rosenblatt, M.D., Renata Laxova, M.D., and Kirk Hogan, M.D., J.D., New England Journal of Medicine, 349;1, July 3, 2003.
A letter in Arch Dis Child 2001;85:510 (December) from Isabel Smith, Clinical Audit Department, Great Ormond Street Hospital in London states: "Nitrous oxide inactivates cobalamin, the active derivative of vitamin B12 and essential cofactor for the transfer of the methyl group from methyltetrahydrofolate to homocysteine to form methionine. For subjects with good body stores of cobalamin this effect is unimportant, but no-one using this agent should remain unaware of the potentially devastating complications in the nervous system of using nitrous oxide in subjects who are of borderline or deficient vitamin B12 status. Onset of subacute combined degeneration affecting the brain and spinal cord is a well documented event when individuals with low body stores of cobalamin are exposed to nitrous oxide."
August 30, 2009 - 12:59pmThis Comment
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