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I am on Desipramine 150 per night. Yes my Psychiatrist knows how depressed I am, I have been seeing him for over 12 months. We have tried a number of antidepressants. I have clinical depression. I know it takes time for the antidepressants to work. Before Desipramime I was taking Imipramine - switched to see if there would be any difference. I push myself each day to keep going and spend a part of each day sobbing in tears. My hope grew when I discontinued the Prometrium, I was my old self. Last months period was wonderful I was myself again, laughing having fun with my kids, only to realize a few days later the depression was back and I spent the next 3 weeks crying, depression has lifted during this months period, I'm not crying, but am having so much anxiety about shutting down my hormones and removing ovaries. I feel we should at least discuss other treatments or at least explain to me what is going on with my hormones. I think I should try estrogen first, My therapist suffers depression and estrogen worked for her.