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Hi Anonymous,

I hate to be the bearer of bad news but yes, progesterone therapy can definitely cause mood swings, fatigue, and irritability. 

Tell your doctor if any of these symptoms are severe or do not go away:

• headache

• breast tenderness or pain

• upset stomach

• vomiting

• diarrhea

• constipation

• tiredness

• muscle, joint, or bone pain

• mood swings

• irritability

• excessive worrying

• runny nose

• sneezing

• cough

• vaginal discharge

• problems urinating

All the best,

Rosa