Acute myeloid leukemia (AML) is fast-growing cancer that starts inside bone marrow, the soft tissue inside bones that helps form blood cells. The cancer grows from cells that would normally turn into white blood cells that help fight infection.
With AML, the bone marrow may also make abnormal red blood cells and platelets. The number of quick-growing abnormal cells (or leukemia cells) crowd out the normal blood cells, white blood cells and platelets the body needs to function normally.
AML is one of the most common types of leukemia among adults. It is more common in men than women. This type of leukemia is rare under age 40; generally occurring around age 65.
Acute myelogenous leukemia is also known as acute myeloid leukemia, acute myeloblastic leukemia, acute granulocytic leukemia and acute nonlymphocytic leukemia.
Leukemia is one of the best studied cancers to date, but the cause of some types, including AML, is still poorly understood. In Feb. 2010, doctors at Abramson Cancer Center of the University of Pennsylvania reported they had found a genetic mutation in AML patients could account for half of the remaining cases of adult acute (fast-growing) leukemia with an unknown origin.
Craig B. Thompson, MD, Abramson Cancer Center director and senior author of the study published online in the peer-review journal Cancer Cell said the mutation could cause between one quarter and one third of AML in older patients.
Other risks leading to some types of leukemia, including AML, are exposure to chemicals such as benzene, certain chemotherapy drugs, including etoposide and alkylating agents, and previous radiation exposure.
AML symptoms include:
- Abnormal menstrual periods
- Bleeding from the nose
- Bleeding gums
- Bone pain and tenderness
- Shortness of breath (worsens with exercise)
- Skin rash or lesion
- Swollen gums (rare)
- weight loss
Treatment typically includes chemotherapy to kill the cancer cells.