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Can Stem Cell Transplants Cause Cancer?

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Stem cell transplants are now being used to treat a variety of neurodegenerative diseases, cancers and brain injury. The stem cells used for such therapy are normally derived from embryos or fetuses, either obtained through termination of pregnancy, or from embryos grown in the lab or leftover from in-vitro fertilization.

Recently, stem cells from cord blood have been used as the blood of a newborn has a very high content of stem cells. They can also be harvested from bone marrow.

There have been lots of studies conducted that show success in treating immune system failure, cancer and other conditions, but the technique is still very much experimental and scientists aren’t completely sure of its safety or effectiveness.
There have been documented cases of embryonic stem cells causing cancer in the recipient, rather than helping, because these cells are prone to forming into tumors rather than helping as they were intended.

For example, a boy with ataxia telangiectasia had fetal stem cells injected into his brain and spine to try to improve the outcome of his condition. Four years later he began having headaches and after medical investigation was found to have brain and spinal tumors at the sites where he was injected. After removal of the spinal tumor, it was found that the tissue did not match his DNA so could have only come from the embryonic cells.

The authors of the case report wrote, "A boy with ataxia telangiectasia (AT) was treated with intracerebellar and intrathecal injection of human fetal neural stem cells. Four years after the first treatment he was diagnosed with a multifocal brain tumor. Studies showed that the tumor was of nonhost origin suggesting it was derived from the transplanted neural stem cells. Further work is urgently needed to assess the safety of these therapies."

The Nature Medicine journal has raised the concern that stem cells can be unstable and have the ability to grow into anything, including cancer, after it caused tumors in rats.

"The goal of replacing dying cells in Parkinson's disease with stem cells is now brought a step closer to the clinic.

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I'm glad you clearly state within the article that it was Embryonic Stem Cells that have been shown to cause cancerous cysts/tumors. Interestingly, Induced Pluripotent Stem Cells also have a history of causing cysts/tumors - http://repairstemcell.wordpress.com/2010/06/29/stem-cell-furore-erupts-nature-news/

ONLY Adult stem cells have no history of causing cysts/tumors and ONLY Adult Stem Cells have proven safe and effective at treating diseases - http://repairstemcell.wordpress.com/2009/10/10/do-stem-cell-treatments-work/

June 29, 2010 - 1:48pm
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