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Genetically Modified Salmonella to Treat Cancer?

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In recent years doctors have blamed the prevalence of asthma and allergies on our lack of exposure to bacteria and on parents keeping their houses super clean. Due to lack of contact with germs, they say, our immune systems aren’t being given the chance to practice and we are becoming weaker as a result.

Now, doctors from University of Minnesota Masonic Cancer Center said that the bacteria salmonella may be useful in fighting cancer. By putting the bacteria into the patient’s body, where the tumor is, they hope it will then destroy the tumor.

The medical profession has known since the 19th century that exposure to infection sometimes cures cancer patients and because of their observations of this, in the 1860’s they decided to do an experiment by putting a patient with a large tumor in the same room as another patient with a serious infection. The tumor became infected and began to shrink rapidly and almost disappeared. Unfortunately the experiment failed because as well as killing the tumor, the infection also killed the patient whose immune system was weakened due to the cancer.

"Many bacteria and viruses - even harmful ones - can be used to fight disease," said Edward Greeno, M.D., lead researcher on the new clinical study and Medical Director of the Masonic Cancer Clinic. "We believe it may even be possible to use bacteria to fight cancer."

He added that to do this they had to to devise a way to introduce the salmonella to the patient without actually making them sick.

The team decided that the way to do this was to turn the salmonella into a weapon by genetically modifying it. They weakened it so that theoretically it wouldn’t cause infection--although other weakened bacteria in medicines have been known to mutate--and then adding Interlueken 2 (IL-2).

Greeno's Medical School colleague, Dan Saltzman, M.D, said, "You could think of IL-2 as a guard dog that sniffs around looking for threats inside the body." When it finds one, it calls in an attack by the immune system it to make it actively detect the tumor.

Salmonella naturally likes to grow inside cancer cells so this seemed the ideal type of bacteria to use to kill cancer.

Add a Comment2 Comments

GMO Salmonella - frightening and insane!
Thanks for writing about this. New to me!

May 9, 2011 - 8:03am
(reply to Susan Beausang)

I know, it is very scary. Salmonella is pretty scary anyway but to make it a super power GMO bacteria, well, I can see the potential as a bioterrorism weapon.

It is probably less toxic than chemo and it probably would kill cancer. My concern is whether it would stay in just that area or spread to other areas of the body and whether it would be capable of mutating. We have seen MRSA in response to antibiotics and a surge in 19a pneumonia in response to prevnar, super power head lice in response to insecticide lotions. How do we know we aren't going to see some ultra super power killer salmonella bug as a result of this? I know Salmonella does sometimes kill but I mean a more severe version that takes even healthy people.

The test subjects are very brave.

May 9, 2011 - 9:28am
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