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Has anyone used and had success with Deplin? Since it's so expensive, does anyone know of cheap places to purchase it?

By Anonymous March 16, 2010 - 10:47am
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My dr. rx Deplin b/c I will not take antidepressants. Does it work for depression? Are there any side effects? I'd be interested in any feedback about this drug.

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EmpowHER Guest

MethylPro makes it for a lot cheaper.

April 8, 2018 - 6:01am
EmpowHER Guest

Last year around January I was unknowingly switched to the generic of Deplin and slowly went down hill. 3 weeks ago my psychiatrist told me to stop taking it again and same
Thing happened. So yes yes it does work

January 1, 2016 - 8:05am
EmpowHER Guest

I have tried every Antidepressant there is and none of them worked for me.
Then about three years ago I started of Deplin and LOVE it! I will tell you that they say it can take up to 10 weeks to tell the difference, and that is how long it took to work for me, but it was worth the wait! I would like you to know that I did the Deplin first then after 3 months changed to L-Methofolate, I prefer the Deplin, I could tell the difference, and the generic for did not irk as well for me. I recently had blood work done for all of my vitamin levels and my Folic level even on Deplin was barely at the Normal level, so now I take 2 , and feel even BETTER!
I suggest anyone who has depression try this first,It has so many benefits.

June 27, 2015 - 6:26am
EmpowHER Guest

I am using Deplin from 2 weeks and didnt noticed any difference yet. I feel that it will work for me. I have purchased it by reading some nice reviews about it online. You can get it from its official website.

May 28, 2014 - 12:12am
EmpowHER Guest

Deplin has worked wonders for me. Started working in literally 3 days. I take 30 mg a day, two 15 mg doses. Been depressed with major depressive disorder for 18 years. Most recently 150 mg Zoloft a day - felt very little or nothing. Deplin is amazing. I truly cannot believe it. Thank GOD !

July 9, 2012 - 6:01am
EmpowHER Guest
Anonymous (reply to Anonymous)

I read to take 7.5 mg at first then no more than 15 mg day. It sounds like 30mg may get faster results if it can be tollerated. Am I right?

April 23, 2018 - 5:06am
EmpowHER Guest

I take effexor XR 150mg and it stopped working, my Dr prescribed Deplin to take in addition. I am only on day 5 of 7.5 mg. I feel energized and happy, something I have not felt in years. I feel very optimistic about this drug.

January 14, 2011 - 1:42am
EmpowHER Guest

I have been taking it 'alone' for a few weeks and it seems to be helping.(7.5mg) i havn't felt sad or blue or depressed etc. wheather its a placebo effect, im not sure but i do want to continue it. im affriad to go off it. its expensive though.
i searched for discounted drug cards, which may help alittle. ($215) my doctor gave me free samples. hopefully he'll continue to do so. if not im going to use a discounted drug card and ask for 15mg and then just cut them in half. i cant take any ani-depressents cuz i have had side effects. i get leg/foot spasams. i have tried prozac and paxcil CR.
Good luck! i hope it helps!

May 24, 2010 - 2:07pm
(reply to Anonymous)

I've been taking it now for about a month. I think it helps altho I'm not sure. I still feel sad alot of the time. I found a pharmacy that charges $80 for the 15mg pill, which I cut in half. I get 2 months for $80 which is still expensive but doable.

Are you still taking it? I went off it for a few days and really felt bad. Don't know if it was me or the Deplin. I don't have any side effects so I suppose I'll stick with it.

July 23, 2010 - 12:31pm

L-methylfolate (brand name: Deplin) may help with symptoms of depression if you lack certain enzymes.

According to the Mayo Clinic,
"Taking L-methylfolate: This prescription supplement provides a form of the B vitamin folic acid, which is necessary for the production of neurotransmitters in the brain linked to mood. Taking this supplement may help with depression if you lack the enzymes to properly break down folate from foods or from standard folic acid supplements."

If you are not interested/unable to take antidepressants, are you also utilizing other treatment options, including psychotherapy? Are you interested in learning about alternative and complementary medicine options that are available? For instance, some individuals have found acupuncture to help treat some of their symptoms.

March 16, 2010 - 2:55pm
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