A handful of antidepressants are prescribed “off-label” for treatment of hot flashes. (“Off-label” means that the drug has been approved by the FDA for treating a disorder, like depression, but not the one affecting you.)
These antidepressants have proven benefits for treating mood disorders and anxiety, but most have not been subjected to the same rigorous hot flash studies as hormone products. They may reduce the flashing, but they won’t help a dry vagina, skin, or bone health.
Furthermore, if you are a breast cancer survivor on Tamoxifen or taking Tamoxifen to reduce your risk of breast cancer, you should not take Paxil (paroxetine) to treat hot flashes as this SSRI has been shown to reduce Tamoxifen levels in some women by affecting the liver metabolism.
Effexor XR has an active isomer, desvenlafaxine, that is being studied in trials for depression as well in trials of menopausal women who are not depressed but have disruptive hot flashes. And as I mentioned in a previous post, under the brand name of Pristiq, it’s likely to become the first nonhormonal medication approved by the FDA for the treatment of hot flashes.
Have you used antidepressants “off label” for hot flashes? What’s your experience?
Original post: http://www.vibrantnation.com/health-fitness/menopause/antidepressants-fo...
All user-generated information on this site is the opinion of its author only and is not a substitute for medical advice or treatment for any medical conditions. Members and guests are responsible for their own posts and the potential consequences of those posts detailed in our Terms of Service.
Add a Comment3 Comments
Hi Vibrant Nation
Thanks for this post!
You raise important points about cross-use of prescriptions - this happens quite a lot.
I hope our readers who have used anti depressants for hot flashes or other menopausal symptoms can give their input here.
Best,
~Susan
November 17, 2011 - 12:20pmThis Comment
I have been on Venlafaxine, Effexor and Sertraline. They all helped my hot flashes. I'm currently taking soy, which is helping. If you try soy, make sure it's non-GMO.
November 17, 2011 - 3:29pmI cannot take the SSRI anti depressants at all--they make me so sick I want to die. But I do have a friend who is taking either Effexor, or Lexapro, I cannot remember, along with patches, and she says it helps her a lot. I know I have read over and over that some of the SSRI's help with hot flashes. Not me, they make me want to die---but I do indeed know other women who swear by them.
November 24, 2011 - 12:44pm