Facebook Pixel
EmpowHER Guest

I want to know what research there is about a trial drug that being used call OFEV

By Anonymous January 12, 2016 - 10:20am
Rate This

My Father has been taking it for about 9 months now and she showing signs of improvement at age 87.. Why can't this drug be used more ? Why is it so expensive ?
This is copied and pasted from the OFEV site so you can see some brief info : "As of now, there is no cure for idiopathic pulmonary fibrosis (IPF). However, there is an IPF treatment called OFEV® (nintedanib). OFEV® may help slow your
IPF progression.

OFEV® is a prescription drug made for adults to treat IPF. It is not known if OFEV® is safe and effective in children. In 3 out of 3 medical studies, IPF patients who took OFEV® found that it slowed the decline in lung function by approximately 50% compared with taking a placebo. This was measured by FVC, which is also one of the measures of disease progression.

Add a Comment1 Comments


Hello Anonymous,

Welcome to EmpowHER. I am so glad to hear that your father is having a positive response to treatment with Ofev (nintedanib).

For the benefit of all our readers, idiopathic pulmonary fibrosis is a condition in which the lungs become progressively scarred over time. As a result, patients with IPF experience shortness of breath, cough, and have difficulty participating in everyday physical activities. Current treatments for IPF include oxygen therapy, pulmonary rehabilitation, and lung transplant.

On October 15, 2014, the U.S. Food and Drug Administration today approved Ofev (nintedanib) for the treatment of idiopathic pulmonary fibrosis (IPF).

The FDA granted Ofev fast track, priority review, orphan product, and breakthrough designations. Ofev is being approved ahead of the product’s prescription drug user fee goal date of Jan. 2, 2015, the date the agency was scheduled to complete the review of the drug application.

Ofev is a kinase inhibitor that blocks multiple pathways that may be involved in the scarring of lung tissue. Its safety and effectiveness were established in three clinical trials of 1,231 patients with IPF. The decline in forced vital capacity – the amount of air which can be forcibly exhaled from the lungs after taking the deepest breath possible – was significantly reduced in patients receiving Ofev compared to patients receiving placebo.

Ofev is not recommended for patients who have moderate to severe liver problems. Ofev can cause birth defects or death to an unborn baby. Women should not become pregnant while taking Ofev. Women who are able to get pregnant should use adequate contraception during and for at least three months after the last dose of Ofev.

The most common side effects of Ofev are diarrhea, nausea, abdominal pain, vomiting, liver enzyme elevation, decreased appetite, headache, decreased weight, and high blood pressure.

Ofev is distributed by Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut.

Here is the link to the full report of "OFEV has been studied in 1231 patients with IPF across 3 clinical trials"

Regarding cost, Boehringer Ingelheim pegged its brand-new treatment, Ofev, at $96,000.
For one, Boehringer has a patient support program in place, dubbed Open Doors, that features 24/7 access to nurse support, financial support resources and additional sources of information. On the access side, the pharma will offer up copay assistance of up to $30,000 per year, and for eligible patients without any financial resources, a patient assistance program will cover the entire cost.

Hope this was the information you were looking for.


January 12, 2016 - 11:00am
Enter the characters shown in the image.
By submitting this form, you agree to EmpowHER's terms of service and privacy policy
Add a Comment

All user-generated information on this site is the opinion of its author only and is not a substitute for medical advice or treatment for any medical conditions. Members and guests are responsible for their own posts and the potential consequences of those posts detailed in our Terms of Service.

Idiopathic Pulmonary Fibrosis

Get Email Updates

Idiopathic Pulmonary Fibrosis Guide

Have a question? We're here to help. Ask the Community.


Health Newsletter

Receive the latest and greatest in women's health and wellness from EmpowHER - for free!