Idiopathic thrombocytopenic purpura (ITP) is a blood disorder. Antibodies produced in the spleen attack and destroy the body’s own blood clotting cells. These cells are called platelets. Platelets help stop bleeding. They travel to a damaged area of the body and stick together. This forms a sort of barrier against germs. It becomes difficult to stop bleeding from injuries if there are not enough platelets in the body.
Although people with ITP have a lower than normal number of platelets in their blood, all of their other blood cell counts are normal.
There are two types of ITP:
Acute ITP—lasts less than six months. This type of ITP usually occurs in children. It is the most common type of ITP.
Chronic ITP—lasts longer than six months. This type of ITP usually occurs in adults.
ITP is treatable. If you think you may have this disorder, contact your physician.
The cause of most cases of ITP is unknown.
In children, the disorder has been linked to a recent viral infection. It is believed that the immune system becomes confused. The confusion cause it to begin attacking healthy platelet cells. When too many platelets are destroyed, ITP can result. The disorder in adults has not been linked to viral infections.
Some cases of ITP are thought to be caused by drugs, infection, or other immune disorders.
Pregnant women sometimes develop the disorder.
The following factors increase your chances of developing ITP:
Children with a recent viral infection or live virus vaccination (may sometimes put a child at a higher risk for developing ITP)
Women, usually younger than 40
Women are 2-3 times more likely to get ITP than in men
If you experience any of the following, do not assume it is due to ITP. These may be caused by other, less serious health conditions. If you experience any one of them, see your doctor.
Both adults and children may notice the following symptoms:
Dark urine or stools
Bleeding for longer than normal following an injury
—A needle is inserted in the skin and into the bone. A small amount of bone marrow is removed. It is tested to be sure there are normal numbers of platelet-producing cells in the marrow. This is done to rule out other disorders.
(in rare cases)—This is done if there is a concern about bleeding in the brain.
Treatment for ITP is different for children and adults. Talk with your doctor about the best plan for you.
Most children recover from ITP without any treatment. However, your doctor may recommend the following treatments:
To increase platelet counts in the blood:
)—lowers the activity of the immune system. This keep its from destroying platelets.
Gamma globulin infusions—are an antibody-containing protein that slows down platelet destruction. An
means that it is given by IV (into vein) or through a shot. It usually works more quickly than steroids.
Both of these treatments work but both can have side effects. Eighty-five percent of children who have ITP recover within a year and do not experience the problem again.
Use of these and also of targeted monoclonal antibody
(Rituxan) may prevent the need for splenectomy.
In adults, if drug intervention does not do enough to raise platelet counts, the doctor may recommend a
Splenectomy is the surgical removal of the spleen. This procedure stops the destruction of platelets since the antibodies are made in the spleen. It also leaves the body more vulnerable to infection from other sources. This surgery is usually not performed until the medications have proven ineffective.
Doctors sometimes recommend lifestyle changes. This may include avoiding contact sports or wearing a helmet, when platelet counts are low.
Since the cause of ITP is unknown, there are no specific ways of preventing it. However, bleeding and injury can be serious for people with ITP.
Take precautions such as padding an infant's crib or play area.
Make sure that older children wear helmets and protective gear when playing sports. This will help to reduce bruising injuries.
When platelet counts are low, contact sports such as football and even rougher game playing may have to be stopped temporarily.
People who have ITP should also avoid medications that contain
. These medicines can reduce platelet function.
To help stay healthy, you should:
. It should be low in saturated fat and rich in whole grains, fruits, and vegetables.
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Please be aware that this information is provided to supplement the care
provided by your physician. It is neither intended nor implied to be a
substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER
IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
advice of your physician or other qualified health provider prior to
starting any new treatment or with any questions you may have regarding a