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Multiple Sclerosis: Genetics, Environment or Both?

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Multiple sclerosis results from damage to the myelin sheath, which covers the axon of the neuron. The myelin sheath is made up from two types of glial cells. The University of Washington explains that oligodendroglial cells make up the myelin sheath in the central nervous system (brain and spinal cord), and the Schwann cells make up the myelin in the peripheral nervous system (nerves in the rest of the body). When the myelin sheath is damaged, the brain cannot properly communicate with the rest of the body.

Arthur Schoenstadt, MD, author of the eMedTV article “Multiple Sclerosis Statistics,” notes that between 250,000 and 350,000 people in the United States have multiple sclerosis, with women being affected twice as often as men. But what causes multiple sclerosis? MedlinePlus, a service of the United States National Library of Medicine and the National Institutes of Health, points out that the exact cause is unknown, though genetics and environmental factors have been studied.


A new study published in Nature Genetics found that a variant of the CBLB gene may cause multiple sclerosis. With the normal gene, it moderates the immune response. But with the abnormal gene, the immune cells attack the healthy cells, as in multiple sclerosis. HealthDay News reports that the researchers analyzed the genes of multiple sclerosis patients in Sardinia, where a large number of autoimmune disorders have been identified. Besides finding the correlation between the variant of the CBLB gene and multiple sclerosis, the researchers also found six other genes associated with multiple sclerosis, which were identified in other studies on the genetics of multiple sclerosis.


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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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