Can Tamoxifen Be Used To Treat Bipolar Disorder? Part 2
In a recently published study from Turkey, close to 50% of manic patients who took the drug Tamoxifen had fewer manic episodes during the three weeks of treatment, compared to just 5% of placebo-treated patients. About 25 percent of Tamoxifen-treated patients and none of the placebo-treated patients achieved remissions.
At the end of three weeks of treatment, the Tamoxifen-treated patients had markedly lower scores on clinical tests designed to measure severity of manic symptoms, while the scores of placebo-treated patients increased slightly. Tamoxifen-treated patients also required less lorazepam in the second and third weeks of the study.
The only negative of the study was that it only involved 50 patents. However, this is not the first study to show that Tamoxifen decreases manic symptoms in individuals with bipolar disorder. A previous National Institute of Mental Health Study reported that 63% of patients had reduced manic symptoms when treated with tamoxifen after three weeks, compared to about less than 10 percent of placebo-treated patients.
Tamoxifen has been observed to be very safe for short-term use.
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