Facebook Pixel

Male Reproductive System Disease: Penile Cancer

By HERWriter
Rate This

Penile cancer is a rare type of cancer that starts at the tip of the penis and spreads. The MD Anderson Cancer Center says the penis contains several types of tissues and different types of penile cancer may develop in these cells.

Cancer.gov reports most penile cancers are squamous cell carcinomas. Other common types are adenocarcinoma, melanomas, basal cell penile cancer and sarcomas.

What causes penile cancer is unknown at this time, doctors do know risk factors associated with it.

Cancer.gov reports men who weren’t circumcised at birth may have a higher risk of developing penile cancer. MD Anderson says phimosis, a condition in which it's difficult to pull back the foreskin, can lead to the buildup of body oils, bacteria and smegma. The National Institutes of Health (NIH) says smegma, a cheese-like, foul-smelling substance, may increase the risk of penis cancer.

Human Papillomavirus (HPV) is also a penile cancer risk factor, as is poor personal hygiene and many sexual partners. Others include being aged 50-70 (although MD Anderson says nearly a third of cases occur in men under 50) and either chewing or smoking tobacco.

Most often penile cancer is first detected when the skin of the penis changes color. LiveStrong.com says symptoms of penile cancer include a painless sore on the penis, genital lesions and pain or bleeding from the penis. Others are reddish rashes and persistent, smelly discharge under the foreskin.

Certain factors affect treatment options. According to Cancer.gov these are the stage of the cancer, the location and size of the tumor; and whether the cancer has just been diagnosed or is recurrent.

NIH says if the tumor is small and near the tip of the penis, surgery to remove only the cancerous part of the penis is possible. This is called a partial penectomy. For more severe tumors, total removal of the penis (total penectomy) is often necessary. A new opening is created in the groin area to allow urine to exit the body.

For very small superficial tumors, MD Anderson says penile cancer may be treated with a laser beam that destroys the tumor, radiation therapy and, in some cases, a cream containing the chemotherapy drug fluorouracil is applied to the skin.

To decrease the risk of penile cancer NIH advises: circumcision or for men who are not circumcised, keep clean the area beneath the foreskin; good personal hygiene; and safe sexual practices, such as abstinence, limiting the number of sexual partners, and use of condoms to prevent HPV infection.


Diseases and Disorders of the Male Reproductive System. LiveStrong.com by Demand Media. Web. 11, Aug 2011.

Cancer – Penis. PubMed Health by the National Center for Biotechnology Information (NCBI). Web. 11, Aug 2011.

Penile Cancer. Cancer.gov by the National Cancer Institute. Web. 11, Aug 2011.

Penile Cancer. MDAnderson.org by the University of Texas MD Anderson Cancer Center. Web. 11, Aug 2011.

Reviewed August 11, 2011
by Michele Blacksberg R.N.
Edited by Jody Smith

Add a CommentComments

There are no comments yet. Be the first one and get the conversation started!

Enter the characters shown in the image.
By submitting this form, you agree to EmpowHER's terms of service and privacy policy

We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

Sexual Health

Get Email Updates

Resource Centers

Related Checklists

Sexual Health Guide

Have a question? We're here to help. Ask the Community.


Health Newsletter

Receive the latest and greatest in women's health and wellness from EmpowHER - for free!