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Is There A Genetic Component To Having Or Being At Risk For A Stroke?

By January 16, 2009 - 3:49pm
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I know many cancers, heart disease and other conditions or diseases have a genetic factor.

I am wondering if the risk of stroke also has a genetic factor to it or is it just a crap shoot on whether you may experience one or not?

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This really helps. Strokes don't really run in my family but knowing people who are recovering from them, it has always been a fear of mine because they can be so debilitating.

Great info - thanks!

January 26, 2009 - 1:35pm
EmpowHER Guest

According to the American Heart Association, yes. The American Heart Association provides the following information about strokes, genetic factors and what can be controlled and what cannot be changed.

What risk factors for stroke can't be changed?
Age — The chance of having a stroke approximately doubles for each decade of life after age 55.  While stroke is common among the elderly, a lot of people under 65 also have strokes.

Heredity (family history) and race — Your stroke risk is greater if a parent, grandparent, sister or brother has had a stroke.  African Americans have a much higher risk of death from a stroke than Caucasians do.  This is partly because blacks have higher risks of high blood pressure, diabetes and obesity.

Sex (gender) — Stroke is more common in men than in women.  In most age groups, more men than women will have a stroke in a given year.  However, more than half of total stroke deaths occur in women.  At all ages, more women than men die of stroke.  Use of birth control pills and pregnancy pose special stroke risks for women.

Prior stroke, TIA or heart attack — The risk of stroke for someone who has already had one is many times that of a person who has not.  Transient ischemic attacks (TIAs) are "warning strokes" that produce stroke-like symptoms but no lasting damage. TIAs are strong predictors of stroke.  A person who's had one or more TIAs is almost 10 times more likely to have a stroke than someone of the same age and sex who hasn't.  Recognizing and treating TIAs can reduce your risk of a major stroke. If you've had a heart attack, you're at higher risk of having a stroke, too. 

What stroke risk factors can be changed, treated or controlled?
High blood pressure — High blood pressure is the most important controllable risk factor for stroke.  Many people believe the effective treatment of high blood pressure is a key reason for the accelerated decline in the death rates for stroke.

Cigarette smoking — In recent years, studies have shown cigarette smoking to be an important risk factor for stroke.  The nicotine and carbon monoxide in cigarette smoke damage the cardiovascular system in many ways.  The use of oral contraceptives combined with cigarette smoking greatly increases stroke risk.

Diabetes mellitus — Diabetes is an independent risk factor for stroke.  Many people with diabetes also have high blood pressure, high blood cholesterol and are overweight.  This increases their risk even more.  While diabetes is treatable, the presence of the disease still increases your risk of stroke.

Carotid or other artery disease — The carotid arteries in your neck supply blood to your brain.  A carotid artery narrowed by fatty deposits from atherosclerosis (plaque buildups in artery walls) may become blocked by a blood clot.  Carotid artery disease is also called carotid artery stenosis.   Peripheral artery disease is the narrowing of blood vessels carrying blood to leg and arm muscles. It's caused by fatty buildups of plaque in artery walls.  People with peripheral artery disease have a higher risk of carotid artery disease, which raises their risk of stroke.

Atrial fibrillation — This heart rhythm disorder raises the risk for stroke.  The heart's upper chambers quiver instead of beating effectively, which can let the blood pool and clot.  If a clot breaks off, enters the bloodstream and lodges in an artery leading to the brain, a stroke results.

Other heart disease — People with coronary heart disease or heart failure have a higher risk of stroke than those with hearts that work normally.  Dilated cardiomyopathy (an enlarged heart), heart valve disease and some types of congenital heart defects also raise the risk of stroke.

Sickle cell disease (also called sickle cell anemia) — This is a genetic disorder that mainly affects African-American and Hispanic children.  "Sickled" red blood cells are less able to carry oxygen to the body's tissues and organs.  These cells also tend to stick to blood vessel walls, which can block arteries to the brain and cause a stroke.
High blood cholesterol — People with high blood cholesterol have an increased risk for stroke.  Also, it appears that low HDL (“good”) cholesterol  is a risk factor for stroke in men, but more data are needed to verify its effect in women.

Poor diet — Diets high in saturated fat, trans fat and cholesterol can raise blood cholesterol levels.   Diets high in sodium (salt) can contribute to increased blood pressure.  Diets with excess calories can contribute to obesity.  Also, a diet containing five or more servings of fruits and vegetables per day may reduce the risk of stroke.
Physical inactivity and obesity — Being inactive, obese or both can increase your risk of high blood pressure, high blood cholesterol, diabetes, heart disease and stroke.  So go on a brisk walk, take the stairs, and do whatever you can to make your life more active.  Try to get a total of at least 30 minutes of activity on most or all days.
What are other, less well-documented risk factors?
Geographic location — Strokes are more common in the southeastern United States than in other areas.  These are the so-called "stroke belt" states.

Socioeconomic factors — There's some evidence that strokes are more common among low-income people than among more affluent people.
Alcohol abuse — Alcohol abuse can lead to multiple medical complications, including stroke.  For those who consume alcohol, a recommendation of no more than two drinks per day for men and no more than one drink per day for nonpregnant women best reflects the state of the science for alcohol and stroke risk.

Drug abuse — Drug addiction is often a chronic relapsing disorder associated with a number of societal and health-related problems.  Drugs that are abused, including cocaine, amphetamines and heroin, have been associated with an increased risk of stroke.

I hope this helps.

January 17, 2009 - 9:11am
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