It wasn’t until 1990 that the Office of Research on Women’s Health at the National Institute of Health was founded. Senator Barbara Mikulski (D-Maryland) teamed with Senator Edward Kennedy to make it happen. They knew that women were being excluded from clinical research at the NIH, as exemplified by the well-known aspirin and heart disease study that had been undertaken. There were 22,000 men who were used as research subjects, and zero women. The findings results were applied to both men and women.
In 1991, Dr. Bernadine Healy wrote in The New England Journal of Medicine, about a situation she named The Yentl Syndrome. Her premise was that women were treated less favorably than men for the management of coronary heart disease.